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10.3389/fmolb.2020.00186 http://scihub22266oqcxt.onion/10.3389/fmolb.2020.00186 32850973!7416604!32850973     free     free     free Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Front+Mol+Biosci 2020 ; 7 (ä): 186 Nephropedia Template TP {{tp|p=32850973|t=2020. A Multi-Targeting Approach to Fight SARS-CoV-2 Attachment |pdf=|usr=}}{{32850973}} gab.com Text A Multi-Targeting Approach to Fight SARS-CoV-2 Attachment JO: Front Mol Biosci http://www.kidney.de/pget.php?&tw=1&pmid=32850973 #FOAvip The public health has declared an international state of emergency due to the spread of a new coronavirus (SARS-CoV-2) representing a real pandemic threat so that to find potential therapeutic agents is a dire need. To this aim, the SARS-CoV-2 spike (S) glycoprotein represents a crucial target for vaccines, therapeutic antibodies, and diagnostics. Since virus binding to ACE-2 alone could not be sufficient to justify such severe infection, in order to facilitate medical countermeasure development and to search for new targets, two further regions of S protein have been taken into consideration here. One is represented by the recently identified ganglioside binding site, exactly localized in our study in the galectin-like domain, and the other one by the putative integrin binding sites contained in the RBD. We propose that a cooperating therapy using inhibitors against multiple targets altogether i.e., ACE2, integrins and sugars could be definitely more effective. Twit Text FOAVip A Multi-Targeting Approach to Fight SARS-CoV-2 Attachment ????Front Mol Biosci http://www.kidney.de/pget.php?&tw=1&pmid=32850973 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=32850973 #FOAvip English Wikipedia <ref>{{Cite pmid|32850973}}</ref> A Multi-Targeting Approach to Fight SARS-CoV-2 Attachment #MMPMID32850973 Pirone L; Del Gatto A; Di Gaetano S; Saviano M; Capasso D; Zaccaro L; Pedone E Front Mol Biosci 2020[]; 7 (ä): 186 PMID32850973show ga The public health has declared an international state of emergency due to the spread of a new coronavirus (SARS-CoV-2) representing a real pandemic threat so that to find potential therapeutic agents is a dire need. To this aim, the SARS-CoV-2 spike (S) glycoprotein represents a crucial target for vaccines, therapeutic antibodies, and diagnostics. Since virus binding to ACE-2 alone could not be sufficient to justify such severe infection, in order to facilitate medical countermeasure development and to search for new targets, two further regions of S protein have been taken into consideration here. One is represented by the recently identified ganglioside binding site, exactly localized in our study in the galectin-like domain, and the other one by the putative integrin binding sites contained in the RBD. We propose that a cooperating therapy using inhibitors against multiple targets altogether i.e., ACE2, integrins and sugars could be definitely more effective. äA Multi-Targeting Approach to Fight SARS-CoV-2 Attachment (epmc).pdf DeepDyve Pubget Overpricing