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10.3389/fimmu.2020.01936

http://scihub22266oqcxt.onion/10.3389/fimmu.2020.01936
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32849650!7426437!32849650
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suck abstract from ncbi

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  • Longer Duration of SARS-CoV-2 Infection in a Case of Mild COVID-19 With Weak Production of the Specific IgM and IgG Antibodies #MMPMID32849650
  • Guo X; Zeng L; Huang Z; He Y; Zhang Z; Zhong Z
  • Front Immunol 2020[]; 11 (ä): 1936 PMID32849650show ga
  • Background: The relationship between SARS-CoV-2-carrying time and specific antibody production has not yet been reported in re-admitted COVID-19 patients. We reported a case of mild COVID-19 with long virus-carrying time, weak production of virus-specific IgG and IgM antibodies, and recurrence of positive SARS-CoV-2 RNA in stool specimens after discharge. Case Presentation: A 27-year-old male was diagnosed as COVID-19 after returning to Meizhou from Wuhan. Despite extremely mild symptoms, the patient was hospitalized for 24 days because of persistent positive SARS-CoV-2 RNA detection. Three days after recovery discharge, he was hospitalized again for 7 days due to a recurrence of the positive SARS-CoV-2 RNA result, while in a good physical condition. Serological assay, using a fluorescent immunochromatography detection kit specific to SARS-CoV-2, showed that SARS-CoV-2-specific IgM antibodies were undetectable and IgG antibodies were very low on day 8 after onset; both of the antibodies seemingly reached top concentrations on day 15 (just a 6-fold increase of the IgG titer), and then decreased, remaining relatively stable from day 25 after onset until discharge. The production of the IgM and IgG targeting SARS-CoV-2 in this very mild case was much lower than that in a severe case of COVID-19 during the same hospitalizing period, and the latter was used as a control. Conclusion: Mild COVID-19 patients could carry SARS-CoV-2 for a long time, which may be related to the weak production of the virus-specific IgG and IgM. Recurrence of positive SARS-CoV-2 RNA could occur in mild COVID-19 possibly due to intermittent virus shedding, so strict quarantine and health surveillance should be taken for all discharged COVID-19 patients to prevent a potential virus spread.
  • |Adult[MESH]
  • |Antibodies, Viral/*immunology[MESH]
  • |Betacoronavirus/genetics/*immunology[MESH]
  • |Coronavirus Infections/*immunology/transmission/virology[MESH]
  • |Humans[MESH]
  • |Immunoglobulin G/*immunology[MESH]
  • |Immunoglobulin M/*immunology[MESH]
  • |Male[MESH]
  • |Pandemics[MESH]
  • |Patient Discharge[MESH]
  • |Patient Readmission[MESH]
  • |Pneumonia, Viral/*immunology/transmission/virology[MESH]
  • |Quarantine/methods[MESH]
  • |RNA, Viral/analysis[MESH]
  • |Virus Shedding[MESH]


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  • suck abstract from ncbi

    1936 ä.11 2020