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10.3389/fphys.2020.00989

http://scihub22266oqcxt.onion/10.3389/fphys.2020.00989
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32848893!7417426!32848893
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suck abstract from ncbi

pmid32848893      Front+Physiol 2020 ; 11 (ä): 989
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  • The Enigma of Endothelium in COVID-19 #MMPMID32848893
  • Kaur S; Tripathi DM; Yadav A
  • Front Physiol 2020[]; 11 (ä): 989 PMID32848893show ga
  • Coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome-related coronavirus-2 (SARS-CoV-2) has affected millions of people globally. Clinically, it presents with mild flu-like symptoms in most cases but can cause respiratory failure in high risk population. With the aim of unearthing newer treatments, scientists all over the globe are striving hard to comprehend the underlying mechanisms of COVID-19. Several studies till date have indicated a dysregulated host immune response as the major cause of COVID-19 induced mortality. In this Perspective, we propose a key role of endothelium, particularly pulmonary endothelium in the pathogenesis of COVID-19. We draw parallels and divergences between COVID-19-induced respiratory distress and bacterial sepsis-induced lung injury and recommend the road ahead with respect to identification of endothelium-based biomarkers and plausible treatments for COVID-19.
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