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10.1292/jvms.20-0049

http://scihub22266oqcxt.onion/10.1292/jvms.20-0049
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32848107!7653327!32848107
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suck abstract from ncbi


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pmid32848107      J+Vet+Med+Sci 2020 ; 82 (10): 1492-1496
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  • Clinical efficacy of combination therapy of itraconazole and prednisolone for treating effusive feline infectious peritonitis #MMPMID32848107
  • Kameshima S; Kimura Y; Doki T; Takano T; Park CH; Itoh N
  • J Vet Med Sci 2020[Oct]; 82 (10): 1492-1496 PMID32848107show ga
  • A 3-month-old male Scottish Fold kitten with pleural fluid and low ratio of albumin to globulin (A/G ratio) was brought to our small animal hospital. Since RNA from the type I feline coronavirus (FCoV) were detected in drained pleural fluid, the cat was tentatively diagnosed with effusive feline infectious peritonitis (FIP). Following the administration of itraconazole and prednisolone, the A/G ratio increased, and the pleural fluid mostly disappeared. The fecal FCoV levels temporarily decreased. However, the cat showed neurological manifestations and was eventually euthanized due to status epilepticus after 38 days of treatment. In conclusion, itraconazole partly exerted a beneficial effect in a cat with FIP. However, further investigation of a possible role of itraconazole in FIP treatment is warranted.
  • |14-alpha Demethylase Inhibitors/administration & dosage/*therapeutic use[MESH]
  • |Animals[MESH]
  • |Anti-Inflammatory Agents/administration & dosage/*therapeutic use[MESH]
  • |Body Fluids/virology[MESH]
  • |Cats[MESH]
  • |Coronavirus, Feline/isolation & purification[MESH]
  • |Feline Infectious Peritonitis/complications/*drug therapy[MESH]
  • |Itraconazole/administration & dosage/*therapeutic use[MESH]
  • |Male[MESH]
  • |Prednisolone/administration & dosage/*therapeutic use[MESH]
  • |RNA, Viral/chemistry[MESH]


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