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10.3390/nu12092561 http://scihub22266oqcxt.onion/10.3390/nu12092561 32847033!7551551!32847033     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Nutrients 2020 ; 12 (9): ä Nephropedia Template TP {{tp|p=32847033|t=2020. Clinical Trials for Use of Melatonin to Fight against COVID-19 Are Urgently Needed |pdf=|usr=}}{{32847033}} gab.com Text Clinical Trials for Use of Melatonin to Fight against COVID-19 Are Urgently Needed JO: Nutrients http://www.kidney.de/pget.php?&tw=1&pmid=32847033 #FOAvip The recent pandemic of COVID-19 has already infected millions of individuals and has resulted in the death of hundreds of thousands worldwide. Based on clinical features, pathology, and the pathogenesis of respiratory disorders induced by this and other highly homogenous coronaviruses, the evidence suggests that excessive inflammation, oxidation, and an exaggerated immune response contribute to COVID-19 pathology; these are caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). This leads to a cytokine storm and subsequent progression triggering acute lung injury (ALI)/acute respiratory distress syndrome (ARDS), and often death. We and others have reported melatonin to be an anti-inflammatory and anti-oxidative molecule with a high safety profile. It is effective in critical care patients by reducing their vascular permeability and anxiety, inducing sedation, and improving their quality of sleep. As melatonin shows no harmful adverse effects in humans, it is imperative to introduce this indoleamine into clinical trials where it might be beneficial for better clinical outcomes as an adjuvant treatment of COVID-19-infected patients. Herein, we strongly encourage health care professionals to test the potential of melatonin for targeting the COVID-19 pandemic. This is urgent, since there is no reliable treatment for this devastating disease. Twit Text FOAVip Clinical Trials for Use of Melatonin to Fight against COVID-19 Are Urgently Needed ????Nutrients http://www.kidney.de/pget.php?&tw=1&pmid=32847033 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=32847033 #FOAvip English Wikipedia <ref>{{Cite pmid|32847033}}</ref> Clinical Trials for Use of Melatonin to Fight against COVID-19 Are Urgently Needed #MMPMID32847033 Kleszczynski K; Slominski AT; Steinbrink K; Reiter RJ Nutrients 2020[Aug]; 12 (9): ä PMID32847033show ga The recent pandemic of COVID-19 has already infected millions of individuals and has resulted in the death of hundreds of thousands worldwide. Based on clinical features, pathology, and the pathogenesis of respiratory disorders induced by this and other highly homogenous coronaviruses, the evidence suggests that excessive inflammation, oxidation, and an exaggerated immune response contribute to COVID-19 pathology; these are caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). This leads to a cytokine storm and subsequent progression triggering acute lung injury (ALI)/acute respiratory distress syndrome (ARDS), and often death. We and others have reported melatonin to be an anti-inflammatory and anti-oxidative molecule with a high safety profile. It is effective in critical care patients by reducing their vascular permeability and anxiety, inducing sedation, and improving their quality of sleep. As melatonin shows no harmful adverse effects in humans, it is imperative to introduce this indoleamine into clinical trials where it might be beneficial for better clinical outcomes as an adjuvant treatment of COVID-19-infected patients. Herein, we strongly encourage health care professionals to test the potential of melatonin for targeting the COVID-19 pandemic. This is urgent, since there is no reliable treatment for this devastating disease. |*Betacoronavirus[MESH] |*Drug Repositioning[MESH] |Anti-Inflammatory Agents/therapeutic use[MESH] |Antioxidants/therapeutic use[MESH] |COVID-19[MESH] |COVID-19 Drug Treatment[MESH] |Clinical Trials as Topic[MESH] |Coronavirus Infections/*drug therapy/virology[MESH] |Humans[MESH] |Melatonin/*therapeutic use[MESH] |Pandemics[MESH] |Pneumonia, Viral/*drug therapy/virology[MESH]Clinical Trials for Use of Melatonin to Fight against COVID-19 Are Urg(epmc).pdf DeepDyve Pubget Overpricing