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10.3390/bios10090106

http://scihub22266oqcxt.onion/10.3390/bios10090106
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32847008!7557795!32847008
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suck abstract from ncbi


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pmid32847008      Biosensors+(Basel) 2020 ; 10 (9): ä
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  • Biosensing Cytokine IL-6: A Comparative Analysis of Natural and Synthetic Receptors #MMPMID32847008
  • Alfinito E; Beccaria M; Ciccarese M
  • Biosensors (Basel) 2020[Aug]; 10 (9): ä PMID32847008show ga
  • Cytokines are a family of proteins which play a major role in the regulation of the immune system and the development of several diseases, from rheumatoid arthritis to cancer and, more recently, COVID-19. Therefore, many efforts are currently being developed to improve therapy and diagnosis, as well as to produce inhibitory drugs and biosensors for a rapid, minimally invasive, and effective detection. In this regard, even more efficient cytokine receptors are under investigation. In this paper we analyze a set of IL-6 cytokine receptors, investigating their topological features by means of a theoretical approach. Our results suggest a topological indicator that may help in the identification of those receptors having the highest complementarity with the protein, a feature expected to ensure a stable binding. Furthermore, we propose and discuss the use of these receptors in an idealized experimental setup.
  • |Antibodies, Monoclonal, Humanized/chemistry/immunology[MESH]
  • |Antibodies, Monoclonal/analysis/immunology[MESH]
  • |Aptamers, Nucleotide/chemistry[MESH]
  • |Betacoronavirus/isolation & purification[MESH]
  • |Biosensing Techniques/*methods[MESH]
  • |COVID-19[MESH]
  • |Coronavirus Infections/diagnosis/metabolism/virology[MESH]
  • |Humans[MESH]
  • |Immunoglobulin Fab Fragments/analysis/immunology[MESH]
  • |Interleukin-6/*analysis/immunology[MESH]
  • |Limit of Detection[MESH]
  • |Pandemics[MESH]
  • |Pneumonia, Viral/diagnosis/metabolism/virology[MESH]
  • |Receptors, Interleukin-6/*analysis/immunology[MESH]


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