Use my Search Websuite to scan PubMed, PMCentral, Journal Hosts and Journal Archives, FullText.
Kick-your-searchterm to multiple Engines kick-your-query now !>
A dictionary by aggregated review articles of nephrology, medicine and the life sciences
Your one-stop-run pathway from word to the immediate pdf of peer-reviewed on-topic knowledge.

suck abstract from ncbi

suck pdf from helios

10.1038/s41586-020-2700-3

http://scihub22266oqcxt.onion/10.1038/s41586-020-2700-3
suck pdf from google scholar
32846427!ä!32846427

suck abstract from ncbi

pmid32846427
Nephropedia Template TP

gab.com Text

Twit Text FOAVip

Twit Text #

English Wikipedia


  • Sex differences in immune responses that underlie COVID-19 disease outcomes #MMPMID32846427
  • Takahashi T; Ellingson MK; Wong P; Israelow B; Lucas C; Klein J; Silva J; Mao T; Oh JE; Tokuyama M; Lu P; Venkataraman A; Park A; Liu F; Meir A; Sun J; Wang EY; Casanovas-Massana A; Wyllie AL; Vogels CBF; Earnest R; Lapidus S; Ott IM; Moore AJ; Shaw A; Fournier JB; Odio CD; Farhadian S; Dela Cruz C; Grubaugh ND; Schulz WL; Ring AM; Ko AI; Omer SB; Iwasaki A
  • Nature 2020[Aug]; ä (ä): ä PMID32846427show ga
  • There is increasing evidence that coronavirus disease 2019 (COVID-19) produces more severe symptoms and higher mortality among men than among women(1-5). However, whether immune responses against severe acute respiratory syndrome coronavirus (SARS-CoV-2) differ between sexes, and whether such differences correlate with the sex difference in the disease course of COVID-19, is currently unknown. Here we examined sex differences in viral loads, SARS-CoV-2-specific antibody titres, plasma cytokines and blood-cell phenotyping in patients with moderate COVID-19 who had not received immunomodulatory medications. Male patients had higher plasma levels of innate immune cytokines such as IL-8 and IL-18 along with more robust induction of non-classical monocytes. By contrast, female patients had more robust T cell activation than male patients during SARS-CoV-2 infection. Notably, we found that a poor T cell response negatively correlated with patients' age and was associated with worse disease outcome in male patients, but not in female patients. By contrast, higher levels of innate immune cytokines were associated with worse disease progression in female patients, but not in male patients. These findings provide a possible explanation for the observed sex biases in COVID-19, and provide an important basis for the development of a sex-based approach to the treatment and care of male and female patients with COVID-19.
  • ä


  • DeepDyve
  • Pubget Overpricing
  • suck abstract from ncbi

    ä ä.ä 2020