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10.1080/22221751.2020.1815591 http://scihub22266oqcxt.onion/10.1080/22221751.2020.1815591 32844713!7534331!32844713     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=32844713&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Emerg+Microbes+Infect 2020 ; 9 (1): 1988-1996 Nephropedia Template TP {{tp|p=32844713|t=2020. Functional mapping of B-cell linear epitopes of SARS-CoV-2 in COVID-19 convalescent population |pdf=|usr=}}{{32844713}} gab.com Text Functional mapping of B-cell linear epitopes of SARS-CoV-2 in COVID-19 convalescent population JO: Emerg Microbes Infect http://www.kidney.de/pget.php?&tw=1&pmid=32844713 #FOAvip ABSTRACT Pandemic SARS-CoV-2 has caused unprecedented mortalities. Vaccine is in urgent need to stop the pandemic. Despite great progresses on SARS-CoV-2 vaccine development, the efficacy of the vaccines remains to be determined. Deciphering the interactions of the viral epitopes with the elicited neutralizing antibodies in convalescent population inspires the vaccine development. In this study, we devised a peptide array composed of 20-mer overlapped peptides of spike (S), membrane (M) and envelope (E) proteins, and performed a screening with 120 COVID-19 convalescent sera and 24 non-COVID-19 sera. We identified five SARS-CoV-2-specific dominant epitopes that reacted with above 40% COVID-19 convalescent sera. Of note, two peptides non-specifically interacted with most of the non-COVID-19 sera. Neutralization assay indicated that only five sera completely blocked viral infection at the dilution of 1:200. By using a peptide-compete neutralizing assay, we found that three dominant epitopes partially competed the neutralization activity of several convalescent sera, suggesting antibodies elicited by these epitopes played an important role in neutralizing viral infection. The epitopes we identified in this study may serve as vaccine candidates to elicit neutralizing antibodies in most vaccinated people or specific antigens for SARS-CoV-2 diagnosis. Twit Text FOAVip Functional mapping of B-cell linear epitopes of SARS-CoV-2 in COVID-19 convalescent population ????Emerg Microbes Infect http://www.kidney.de/pget.php?&tw=1&pmid=32844713 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=32844713 #FOAvip English Wikipedia <ref>{{Cite pmid|32844713}}</ref> Functional mapping of B-cell linear epitopes of SARS-CoV-2 in COVID-19 convalescent population #MMPMID32844713 Yi Z; Ling Y; Zhang X; Chen J; Hu K; Wang Y; Song W; Ying T; Zhang R; Lu H; Yuan Z Emerg Microbes Infect 2020[Dec]; 9 (1): 1988-1996 PMID32844713show ga ABSTRACT Pandemic SARS-CoV-2 has caused unprecedented mortalities. Vaccine is in urgent need to stop the pandemic. Despite great progresses on SARS-CoV-2 vaccine development, the efficacy of the vaccines remains to be determined. Deciphering the interactions of the viral epitopes with the elicited neutralizing antibodies in convalescent population inspires the vaccine development. In this study, we devised a peptide array composed of 20-mer overlapped peptides of spike (S), membrane (M) and envelope (E) proteins, and performed a screening with 120 COVID-19 convalescent sera and 24 non-COVID-19 sera. We identified five SARS-CoV-2-specific dominant epitopes that reacted with above 40% COVID-19 convalescent sera. Of note, two peptides non-specifically interacted with most of the non-COVID-19 sera. Neutralization assay indicated that only five sera completely blocked viral infection at the dilution of 1:200. By using a peptide-compete neutralizing assay, we found that three dominant epitopes partially competed the neutralization activity of several convalescent sera, suggesting antibodies elicited by these epitopes played an important role in neutralizing viral infection. The epitopes we identified in this study may serve as vaccine candidates to elicit neutralizing antibodies in most vaccinated people or specific antigens for SARS-CoV-2 diagnosis. |Animals[MESH] |Antibodies, Neutralizing/*blood[MESH] |Antibodies, Viral/*blood[MESH] |B-Lymphocytes/immunology[MESH] |Betacoronavirus/*immunology[MESH] |COVID-19[MESH] |COVID-19 Serotherapy[MESH] |Cell Line[MESH] |Chlorocebus aethiops[MESH] |Coronavirus Infections/diagnosis/immunology/*prevention & control/therapy[MESH] |Epitopes, B-Lymphocyte/*immunology[MESH] |Humans[MESH] |Immunization, Passive[MESH] |Pandemics/*prevention & control[MESH] |Pneumonia, Viral/diagnosis/immunology/*prevention & control[MESH] |SARS-CoV-2[MESH] |Spike Glycoprotein, Coronavirus/immunology[MESH] |Vero Cells[MESH] |Viral Envelope Proteins/immunology[MESH]Functional mapping of B-cell linear epitopes of SARS-CoV-2 in COVID-19(epmc).pdf DeepDyve Pubget Overpricing