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Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Influenza+Other+Respir+Viruses 2021 ; 15 (1): 7-12 Nephropedia Template TP
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Human post-infection serological response to the spike and nucleocapsid proteins of SARS-CoV-2 #MMPMID32844604
Xiao C; Ling S; Qiu M; Deng Z; Chen L; Zhu A; Chen Y; Liu Y; Lin X; Lin F; Wu Q; Shen L; Ye F; Liu X; Li Y; Zhao J; Yang Z; Cowling BJ; Webby R; Zanin M; Wong SS
Influenza Other Respir Viruses 2021[Jan]; 15 (1): 7-12 PMID32844604show ga
To inform seroepidemiological studies, we characterized the IgG- responses in COVID-19 patients against the two major SARS-CoV-2 viral proteins, spike (S) and nucleocapsid (N). We tested 70 COVID-19 sera collected up to 85 days post-symptom onset and 230 non-COVID-19 sera, including 27 SARS sera from 2003. Although the average SARS-CoV-2 S and N-IgG titers were comparable, N-responses were more variable among individuals. S- and N-assay specificity tested with non-COVID-19 sera were comparable at 97.5% and 97.0%, respectively. Therefore, S will make a better target due to its lower cross-reactive potential and its' more consistent frequency of detection compared to N.