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10.1111/irv.12798

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32844604!7461388!32844604
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suck abstract from ncbi


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pmid32844604      Influenza+Other+Respir+Viruses 2021 ; 15 (1): 7-12
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  • Human post-infection serological response to the spike and nucleocapsid proteins of SARS-CoV-2 #MMPMID32844604
  • Xiao C; Ling S; Qiu M; Deng Z; Chen L; Zhu A; Chen Y; Liu Y; Lin X; Lin F; Wu Q; Shen L; Ye F; Liu X; Li Y; Zhao J; Yang Z; Cowling BJ; Webby R; Zanin M; Wong SS
  • Influenza Other Respir Viruses 2021[Jan]; 15 (1): 7-12 PMID32844604show ga
  • To inform seroepidemiological studies, we characterized the IgG- responses in COVID-19 patients against the two major SARS-CoV-2 viral proteins, spike (S) and nucleocapsid (N). We tested 70 COVID-19 sera collected up to 85 days post-symptom onset and 230 non-COVID-19 sera, including 27 SARS sera from 2003. Although the average SARS-CoV-2 S and N-IgG titers were comparable, N-responses were more variable among individuals. S- and N-assay specificity tested with non-COVID-19 sera were comparable at 97.5% and 97.0%, respectively. Therefore, S will make a better target due to its lower cross-reactive potential and its' more consistent frequency of detection compared to N.
  • |Adult[MESH]
  • |Aged[MESH]
  • |Aged, 80 and over[MESH]
  • |Antibodies, Viral/*blood[MESH]
  • |Coronavirus Nucleocapsid Proteins/*immunology[MESH]
  • |Cross Reactions[MESH]
  • |Humans[MESH]
  • |Middle Aged[MESH]
  • |Phosphoproteins/immunology[MESH]
  • |SARS-CoV-2/*immunology[MESH]
  • |Severe acute respiratory syndrome-related coronavirus/immunology[MESH]


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