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Am J Transplant 2020[Nov]; 20 (11): 3061-3071 PMID32844546show ga
National data on patient characteristics, treatment, and outcomes of critically ill coronavirus disease 2019 (COVID-19) solid organ transplant (SOT) patients are limited. We analyzed data from a multicenter cohort study of adults with laboratory-confirmed COVID-19 admitted to intensive care units (ICUs) at 68 hospitals across the United States from March 4 to May 8, 2020. From 4153 patients, we created a propensity score matched cohort of 386 patients, including 98 SOT patients and 288 non-SOT patients. We used a binomial generalized linear model (log-binomial model) to examine the association of SOT status with death and other clinical outcomes. Among the 386 patients, the median age was 60 years, 72% were male, and 41% were black. Death within 28 days of ICU admission was similar in SOT and non-SOT patients (40% and 43%, respectively; relative risk [RR] 0.92; 95% confidence interval [CI]: 0.70-1.22). Other outcomes and requirement for organ support including receipt of mechanical ventilation, development of acute respiratory distress syndrome, and receipt of vasopressors were also similar between groups. There was a trend toward higher risk of acute kidney injury requiring renal replacement therapy in SOT vs. non-SOT patients (37% vs. 27%; RR [95% CI]: 1.34 [0.97-1.85]). Death and organ support requirement were similar between SOT and non-SOT critically ill patients with COVID-19.
|*Organ Transplantation[MESH]
|*Pandemics[MESH]
|*SARS-CoV-2[MESH]
|Aged[MESH]
|COVID-19/*epidemiology[MESH]
|Comorbidity[MESH]
|Critical Illness/epidemiology/*therapy[MESH]
|Female[MESH]
|Follow-Up Studies[MESH]
|Hospital Mortality/trends[MESH]
|Hospitalization/*trends[MESH]
|Humans[MESH]
|Intensive Care Units/*statistics & numerical data[MESH]