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10.1002/rmv.2157 http://scihub22266oqcxt.onion/10.1002/rmv.2157 32844538!7461031!32844538     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=32844538&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Rev+Med+Virol 2021 ; 31 (2): e2157 Nephropedia Template TP {{tp|p=32844538|t=2021. Alpha-1-antitrypsin: A possible host protective factor against Covid-19 |pdf=|usr=}}{{32844538}} gab.com Text Alpha-1-antitrypsin: A possible host protective factor against Covid-19 JO: Rev Med Virol http://www.kidney.de/pget.php?&tw=1&pmid=32844538 #FOAvip Understanding Covid-19 pathophysiology is crucial for a better understanding of the disease and development of more effective treatments. Alpha-1-antitrypsin (A1AT) is a constitutive tissue protector with antiviral and anti-inflammatory properties. A1AT inhibits SARS-CoV-2 infection and two of the most important proteases in the pathophysiology of Covid-19: the transmembrane serine protease 2 (TMPRSS2) and the disintegrin and metalloproteinase 17 (ADAM17). It also inhibits the activity of inflammatory molecules, such as IL-8, TNF-alpha, and neutrophil elastase (NE). TMPRSS2 is essential for SARS-CoV-2-S protein priming and viral infection. ADAM17 mediates ACE2, IL-6R, and TNF-alpha shedding. ACE2 is the SARS-CoV-2 entry receptor and a key component for the balance of the renin-angiotensin system, inflammation, vascular permeability, and pulmonary homeostasis. In addition, clinical findings indicate that A1AT levels might be important in defining Covid-19 outcomes, potentially partially explaining associations with air pollution and with diabetes. In this review, we focused on the interplay between A1AT with TMPRSS2, ADAM17 and immune molecules, and the role of A1AT in the pathophysiology of Covid-19, opening new avenues for investigating effective treatments. Twit Text FOAVip Alpha-1-antitrypsin: A possible host protective factor against Covid-19 ????Rev Med Virol http://www.kidney.de/pget.php?&tw=1&pmid=32844538 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=32844538 #FOAvip English Wikipedia <ref>{{Cite pmid|32844538}}</ref> Alpha-1-antitrypsin: A possible host protective factor against Covid-19 #MMPMID32844538 de Loyola MB; Dos Reis TTA; de Oliveira GXLM; da Fonseca Palmeira J; Arganaraz GA; Arganaraz ER Rev Med Virol 2021[Mar]; 31 (2): e2157 PMID32844538show ga Understanding Covid-19 pathophysiology is crucial for a better understanding of the disease and development of more effective treatments. Alpha-1-antitrypsin (A1AT) is a constitutive tissue protector with antiviral and anti-inflammatory properties. A1AT inhibits SARS-CoV-2 infection and two of the most important proteases in the pathophysiology of Covid-19: the transmembrane serine protease 2 (TMPRSS2) and the disintegrin and metalloproteinase 17 (ADAM17). It also inhibits the activity of inflammatory molecules, such as IL-8, TNF-alpha, and neutrophil elastase (NE). TMPRSS2 is essential for SARS-CoV-2-S protein priming and viral infection. ADAM17 mediates ACE2, IL-6R, and TNF-alpha shedding. ACE2 is the SARS-CoV-2 entry receptor and a key component for the balance of the renin-angiotensin system, inflammation, vascular permeability, and pulmonary homeostasis. In addition, clinical findings indicate that A1AT levels might be important in defining Covid-19 outcomes, potentially partially explaining associations with air pollution and with diabetes. In this review, we focused on the interplay between A1AT with TMPRSS2, ADAM17 and immune molecules, and the role of A1AT in the pathophysiology of Covid-19, opening new avenues for investigating effective treatments. |ADAM17 Protein/metabolism[MESH] |Animals[MESH] |COVID-19/*metabolism[MESH] |Humans[MESH] |Protective Factors[MESH] |Serine Endopeptidases/metabolism[MESH]Alpha-1-antitrypsin: A possible host protective factor against Covid-1(epmc).pdf DeepDyve Pubget Overpricing