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Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Biochem+Biophys+Rep 2020 ; 24 (ä): 100798 Nephropedia Template TP
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ACE2 coding variants in different populations and their potential impact on SARS-CoV-2 binding affinity #MMPMID32844124
Ali F; Elserafy M; Alkordi MH; Amin M
Biochem Biophys Rep 2020[Dec]; 24 (ä): 100798 PMID32844124show ga
The susceptibility of different populations to SARS-CoV-2 infection is not yet understood. Here, we combined ACE2 coding variants' analysis in different populations and computational chemistry calculations to probe the effects on SARS-CoV-2/ACE2 interaction. ACE2-K26R; which is most frequent in Ashkenazi Jewish population decreased the SARS-CoV-2/ACE2 electrostatic attraction. On the contrary, ACE2-I468V, R219C, K341R, D206G, G211R increased the electrostatic attraction; ordered by binding strength from weakest to strongest. The aforementioned variants are most frequent in East Asian, South Asian, African and African American, European, European and South Asian populations, respectively.