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Origin and cross-species transmission of bat coronaviruses in China #MMPMID32843626
Latinne A; Hu B; Olival KJ; Zhu G; Zhang L; Li H; Chmura AA; Field HE; Zambrana-Torrelio C; Epstein JH; Li B; Zhang W; Wang LF; Shi ZL; Daszak P
Nat Commun 2020[Aug]; 11 (1): 4235 PMID32843626show ga
Bats are presumed reservoirs of diverse coronaviruses (CoVs) including progenitors of Severe Acute Respiratory Syndrome (SARS)-CoV and SARS-CoV-2, the causative agent of COVID-19. However, the evolution and diversification of these coronaviruses remains poorly understood. Here we use a Bayesian statistical framework and a large sequence data set from bat-CoVs (including 630 novel CoV sequences) in China to study their macroevolution, cross-species transmission and dispersal. We find that host-switching occurs more frequently and across more distantly related host taxa in alpha- than beta-CoVs, and is more highly constrained by phylogenetic distance for beta-CoVs. We show that inter-family and -genus switching is most common in Rhinolophidae and the genus Rhinolophus. Our analyses identify the host taxa and geographic regions that define hotspots of CoV evolutionary diversity in China that could help target bat-CoV discovery for proactive zoonotic disease surveillance. Finally, we present a phylogenetic analysis suggesting a likely origin for SARS-CoV-2 in Rhinolophus spp. bats.
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Nat+Commun 2020 ; 11 (1): 4235
