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10.3390/molecules25173830 http://scihub22266oqcxt.onion/10.3390/molecules25173830 32842509!7503980!32842509     free     free     free Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Molecules 2020 ; 25 (17): ä Nephropedia Template TP {{tp|p=32842509|t=2020. Drug Repurposing for Candidate SARS-CoV-2 Main Protease Inhibitors by a Novel In Silico Method |pdf=|usr=}}{{32842509}} gab.com Text Drug Repurposing for Candidate SARS-CoV-2 Main Protease Inhibitors by a Novel In Silico Method JO: Molecules http://www.kidney.de/pget.php?&tw=1&pmid=32842509 #FOAvip The SARS-CoV-2 outbreak caused an unprecedented global public health threat, having a high transmission rate with currently no drugs or vaccines approved. An alternative powerful additional approach to counteract COVID-19 is in silico drug repurposing. The SARS-CoV-2 main protease is essential for viral replication and an attractive drug target. In this study, we used the virtual screening protocol with both long-range and short-range interactions to select candidate SARS-CoV-2 main protease inhibitors. First, the Informational spectrum method applied for small molecules was used for searching the Drugbank database and further followed by molecular docking. After in silico screening of drug space, we identified 57 drugs as potential SARS-CoV-2 main protease inhibitors that we propose for further experimental testing. Twit Text FOAVip Drug Repurposing for Candidate SARS-CoV-2 Main Protease Inhibitors by a Novel In Silico Method ????Molecules http://www.kidney.de/pget.php?&tw=1&pmid=32842509 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=32842509 #FOAvip English Wikipedia <ref>{{Cite pmid|32842509}}</ref> Drug Repurposing for Candidate SARS-CoV-2 Main Protease Inhibitors by a Novel In Silico Method #MMPMID32842509 Sencanski M; Perovic V; Pajovic SB; Adzic M; Paessler S; Glisic S Molecules 2020[Aug]; 25 (17): ä PMID32842509show ga The SARS-CoV-2 outbreak caused an unprecedented global public health threat, having a high transmission rate with currently no drugs or vaccines approved. An alternative powerful additional approach to counteract COVID-19 is in silico drug repurposing. The SARS-CoV-2 main protease is essential for viral replication and an attractive drug target. In this study, we used the virtual screening protocol with both long-range and short-range interactions to select candidate SARS-CoV-2 main protease inhibitors. First, the Informational spectrum method applied for small molecules was used for searching the Drugbank database and further followed by molecular docking. After in silico screening of drug space, we identified 57 drugs as potential SARS-CoV-2 main protease inhibitors that we propose for further experimental testing. |Allosteric Site[MESH] |Antiviral Agents/*chemistry/pharmacology[MESH] |Betacoronavirus/*drug effects/enzymology/pathogenicity[MESH] |COVID-19[MESH] |Catalytic Domain[MESH] |Coronavirus 3C Proteases[MESH] |Coronavirus Infections/drug therapy/enzymology/virology[MESH] |Cysteine Endopeptidases/*chemistry/genetics/metabolism[MESH] |Drug Repositioning[MESH] |Gene Expression[MESH] |High-Throughput Screening Assays[MESH] |Humans[MESH] |Mezlocillin/*chemistry/pharmacology[MESH] |Molecular Docking Simulation[MESH] |Pandemics[MESH] |Pneumonia, Viral/drug therapy/enzymology/virology[MESH] |Protease Inhibitors/*chemistry/pharmacology[MESH] |Protein Binding[MESH] |Protein Conformation, alpha-Helical[MESH] |Protein Conformation, beta-Strand[MESH] |Protein Interaction Domains and Motifs[MESH] |Raltegravir Potassium/*chemistry/pharmacology[MESH] |SARS-CoV-2[MESH] |Thermodynamics[MESH] |Viral Nonstructural Proteins/antagonists & inhibitors/*chemistry/genetics/metabolism[MESH]Drug Repurposing for Candidate SARS-CoV-2 Main Protease Inhibitors by (epmc).pdf DeepDyve Pubget Overpricing