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10.3390/v12090924 http://scihub22266oqcxt.onion/10.3390/v12090924 32842491!7552024!32842491     free     free     free       Viruses 2020 ; 12 (9): ä Nephropedia Template TP {{tp|p=32842491|t=2020. Viral Vectors Applied for RNAi-Based Antiviral Therapy |pdf=|usr=}}{{32842491}} gab.com Text Viral Vectors Applied for RNAi-Based Antiviral Therapy JO: Viruses http://www.kidney.de/pget.php?&tw=1&pmid=32842491 #FOAvip RNA interference (RNAi) provides the means for alternative antiviral therapy. Delivery of RNAi in the form of short interfering RNA (siRNA), short hairpin RNA (shRNA) and micro-RNA (miRNA) have demonstrated efficacy in gene silencing for therapeutic applications against viral diseases. Bioinformatics has played an important role in the design of efficient RNAi sequences targeting various pathogenic viruses. However, stability and delivery of RNAi molecules have presented serious obstacles for reaching therapeutic efficacy. For this reason, RNA modifications and formulation of nanoparticles have proven useful for non-viral delivery of RNAi molecules. On the other hand, utilization of viral vectors and particularly self-replicating RNA virus vectors can be considered as an attractive alternative. In this review, examples of antiviral therapy applying RNAi-based approaches in various animal models will be described. Due to the current coronavirus pandemic, a special emphasis will be dedicated to targeting Coronavirus Disease-19 (COVID-19). Twit Text FOAVip Viral Vectors Applied for RNAi-Based Antiviral Therapy ????Viruses http://www.kidney.de/pget.php?&tw=1&pmid=32842491 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=32842491 #FOAvip English Wikipedia <ref>{{Cite pmid|32842491}}</ref> Viral Vectors Applied for RNAi-Based Antiviral Therapy #MMPMID32842491 Lundstrom K Viruses 2020[Aug]; 12 (9): ä PMID32842491show ga RNA interference (RNAi) provides the means for alternative antiviral therapy. Delivery of RNAi in the form of short interfering RNA (siRNA), short hairpin RNA (shRNA) and micro-RNA (miRNA) have demonstrated efficacy in gene silencing for therapeutic applications against viral diseases. Bioinformatics has played an important role in the design of efficient RNAi sequences targeting various pathogenic viruses. However, stability and delivery of RNAi molecules have presented serious obstacles for reaching therapeutic efficacy. For this reason, RNA modifications and formulation of nanoparticles have proven useful for non-viral delivery of RNAi molecules. On the other hand, utilization of viral vectors and particularly self-replicating RNA virus vectors can be considered as an attractive alternative. In this review, examples of antiviral therapy applying RNAi-based approaches in various animal models will be described. Due to the current coronavirus pandemic, a special emphasis will be dedicated to targeting Coronavirus Disease-19 (COVID-19). |*RNA Interference[MESH] |Animals[MESH] |Antiviral Agents/therapeutic use[MESH] |COVID-19[MESH] |Computational Biology[MESH] |Coronavirus Infections/*therapy[MESH] |Gene Silencing[MESH] |Humans[MESH] |Immunocompromised Host[MESH] |Pandemics[MESH]Viral Vectors Applied for RNAi-Based Antiviral Therapy (epmc).pdf DeepDyve Pubget Overpricing