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10.1016/j.ijid.2020.08.052 http://scihub22266oqcxt.onion/10.1016/j.ijid.2020.08.052 32841689!7443060!32841689     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Int+J+Infect+Dis 2020 ; 100 (ä): 216-223 Nephropedia Template TP {{tp|p=32841689|t=2020. A genetic barcode of SARS-CoV-2 for monitoring global distribution of different clades during the COVID-19 pandemic |pdf=|usr=}}{{32841689}} gab.com Text A genetic barcode of SARS-CoV-2 for monitoring global distribution of different clades during the COVID-19 pandemic JO: Int J Infect Dis http://www.kidney.de/pget.php?&tw=1&pmid=32841689 #FOAvip OBJECTIVE: The SARS-CoV-2 pathogen has established endemicity in humans. This necessitates the development of rapid genetic surveillance methodologies to serve as an adjunct with existing comprehensive, albeit though slower, genome sequencing-driven approaches. METHODS: A total of 21,789 complete genomes were downloaded from GISAID on May 28, 2020 for analyses. We have defined the major clades and subclades of circulating SARS-CoV-2 genomes. A rapid sequencing-based genotyping protocol was developed and tested on SARS-CoV-2-positive RNA samples by next-generation sequencing. RESULTS: We describe 11 major mutations which defined five major clades (G(614), S(84), V(251), I(378) and D(392)) of globally circulating viral populations. The clades can specifically identify using an 11-nucleotide genetic barcode. An analysis of amino acid variation in SARS-CoV-2 proteins provided evidence of substitution events in the viral proteins involved in both host entry and genome replication. CONCLUSION: Globally circulating SARS-CoV-2 genomes could be classified into 5 major clades based on mutational profiles defined by an 11-nucleotide barcode. We have successfully developed a multiplexed sequencing-based, rapid genotyping protocol for high-throughput classification of major clade types of SARS-CoV-2 in clinical samples. This barcoding strategy will be required to monitor decreases in genetic diversity as treatment and vaccine approaches become widely available. Twit Text FOAVip A genetic barcode of SARS-CoV-2 for monitoring global distribution of different clades during the COVID-19 pandemic ????Int J Infect Dis http://www.kidney.de/pget.php?&tw=1&pmid=32841689 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=32841689 #FOAvip English Wikipedia <ref>{{Cite pmid|32841689}}</ref> A genetic barcode of SARS-CoV-2 for monitoring global distribution of different clades during the COVID-19 pandemic #MMPMID32841689 Guan Q; Sadykov M; Mfarrej S; Hala S; Naeem R; Nugmanova R; Al-Omari A; Salih S; Al Mutair A; Carr MJ; Hall WW; Arold ST; Pain A Int J Infect Dis 2020[Nov]; 100 (ä): 216-223 PMID32841689show ga OBJECTIVE: The SARS-CoV-2 pathogen has established endemicity in humans. This necessitates the development of rapid genetic surveillance methodologies to serve as an adjunct with existing comprehensive, albeit though slower, genome sequencing-driven approaches. METHODS: A total of 21,789 complete genomes were downloaded from GISAID on May 28, 2020 for analyses. We have defined the major clades and subclades of circulating SARS-CoV-2 genomes. A rapid sequencing-based genotyping protocol was developed and tested on SARS-CoV-2-positive RNA samples by next-generation sequencing. RESULTS: We describe 11 major mutations which defined five major clades (G(614), S(84), V(251), I(378) and D(392)) of globally circulating viral populations. The clades can specifically identify using an 11-nucleotide genetic barcode. An analysis of amino acid variation in SARS-CoV-2 proteins provided evidence of substitution events in the viral proteins involved in both host entry and genome replication. CONCLUSION: Globally circulating SARS-CoV-2 genomes could be classified into 5 major clades based on mutational profiles defined by an 11-nucleotide barcode. We have successfully developed a multiplexed sequencing-based, rapid genotyping protocol for high-throughput classification of major clade types of SARS-CoV-2 in clinical samples. This barcoding strategy will be required to monitor decreases in genetic diversity as treatment and vaccine approaches become widely available. |*Genome, Viral[MESH] |*Molecular Typing[MESH] |COVID-19/epidemiology/*virology[MESH] |High-Throughput Nucleotide Sequencing[MESH] |Humans[MESH] |Mutation[MESH] |Pandemics[MESH] |SARS-CoV-2/classification/*genetics[MESH]A genetic barcode of SARS-CoV-2 for monitoring global distribution of (epmc).pdf DeepDyve Pubget Overpricing