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10.1016/j.mvr.2020.104064

http://scihub22266oqcxt.onion/10.1016/j.mvr.2020.104064
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32841626!7443052!32841626
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suck abstract from ncbi


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pmid32841626      Microvasc+Res 2020 ; 132 (ä): 104064
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  • Sublingual microcirculation in patients with SARS-CoV-2 undergoing veno-venous extracorporeal membrane oxygenation #MMPMID32841626
  • Carsetti A; Damiani E; Casarotta E; Scorcella C; Domizi R; Montomoli J; Gasparri F; Gabbanelli V; Pantanetti S; Carozza R; Adrario E; Donati A
  • Microvasc Res 2020[Nov]; 132 (ä): 104064 PMID32841626show ga
  • Veno-Venous Extracorporeal Membrane Oxygenation (VV-ECMO) is a rescue treatment for severe acute respiratory failure refractory to conventional ventilation. We examined the alterations of sublingual microcirculation in patients with SARS-CoV-2 during VV-ECMO treatment and assessed the relationship between microvascular parameters and ventilation, hemodynamics, and laboratory tests. Nine patients were included in the study and the following microcirculatory parameters were estimated: TVD 16.81 (14.46-18.6) mm/mm(2); PVD 15.3 (14.09-17.96) mm/mm(2); PPV 94.85% (93.82%-97.79%); MFI 2.5 (2.5-2.92); HI 0.4 (0.18-0.4). TVD and PVD were inversely related to D-dimer levels (rho = -0.667, p = 0.05 and rho = -0.733, p = 0.025 respectively), aspartate aminotransferase (AST) (rho = -0.886, p = 0.019 and rho = -0.886, p = 0.019 respectively) and alanine aminotransferase (ALT) (rho = -0.829, p = 0.042 and rho = -0.829, p = 0.042 respectively). Our results showed an altered sublingual microcirculation in patients receiving VV-ECMO for severe SARS-CoV-2 and suggest a potential contribution of endothelia dysfunction to determine microvascular alteration.
  • |*Microcirculation[MESH]
  • |Betacoronavirus[MESH]
  • |COVID-19[MESH]
  • |Capillaries/physiopathology[MESH]
  • |Coronavirus Infections/*blood/*therapy[MESH]
  • |Endothelium, Vascular/physiopathology[MESH]
  • |Extracorporeal Membrane Oxygenation/*methods[MESH]
  • |Female[MESH]
  • |Fibrin Fibrinogen Degradation Products/analysis[MESH]
  • |Hemodynamics[MESH]
  • |Humans[MESH]
  • |Male[MESH]
  • |Microscopy, Video[MESH]
  • |Middle Aged[MESH]
  • |Mouth Floor/*blood supply[MESH]
  • |Pandemics[MESH]
  • |Pneumonia, Viral/*blood/*therapy[MESH]
  • |Retrospective Studies[MESH]
  • |SARS-CoV-2[MESH]


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