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10.1016/j.bbamem.2020.183445 http://scihub22266oqcxt.onion/10.1016/j.bbamem.2020.183445 32841614!7443088!32841614     free     free     free Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Biochim+Biophys+Acta+Biomembr 2021 ; 1863 (1): 183445 Nephropedia Template TP {{tp|p=32841614|t=2021. Structure and function of proteins in membranes and nanodiscs |pdf=|usr=}}{{32841614}} gab.com Text Structure and function of proteins in membranes and nanodiscs JO: Biochim Biophys Acta Biomembr http://www.kidney.de/pget.php?&tw=1&pmid=32841614 #FOAvip The field of membrane structural biology represents a fast-moving field with exciting developments including native nanodiscs that allow preparation of complexes of post-translationally modified proteins bound to biological lipids. This has led to conceptual advances including biological membrane:protein assemblies or "memteins" as the fundamental functional units of biological membranes. Tools including cryo-electron microscopy and X-ray crystallography are maturing such that it is becoming increasingly feasible to solve structures of large, multicomponent complexes, while complementary methods including nuclear magnetic resonance spectroscopy yield unique insights into interactions and dynamics. Challenges remain, including elucidating exactly how lipids and ligands are recognized at atomic resolution and transduce signals across asymmetric bilayers. In this special volume some of the latest thinking and methods are gathered through the analysis of a range of transmembrane targets. Ongoing work on areas including polymer design, protein labelling and microfluidic technologies will ensure continued progress on improving resolution and throughput, providing deeper understanding of this most important group of targets. Twit Text FOAVip Structure and function of proteins in membranes and nanodiscs ????Biochim Biophys Acta Biomembr http://www.kidney.de/pget.php?&tw=1&pmid=32841614 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=32841614 #FOAvip English Wikipedia <ref>{{Cite pmid|32841614}}</ref> Structure and function of proteins in membranes and nanodiscs #MMPMID32841614 Lemieux MJ; Overduin M Biochim Biophys Acta Biomembr 2021[Jan]; 1863 (1): 183445 PMID32841614show ga The field of membrane structural biology represents a fast-moving field with exciting developments including native nanodiscs that allow preparation of complexes of post-translationally modified proteins bound to biological lipids. This has led to conceptual advances including biological membrane:protein assemblies or "memteins" as the fundamental functional units of biological membranes. Tools including cryo-electron microscopy and X-ray crystallography are maturing such that it is becoming increasingly feasible to solve structures of large, multicomponent complexes, while complementary methods including nuclear magnetic resonance spectroscopy yield unique insights into interactions and dynamics. Challenges remain, including elucidating exactly how lipids and ligands are recognized at atomic resolution and transduce signals across asymmetric bilayers. In this special volume some of the latest thinking and methods are gathered through the analysis of a range of transmembrane targets. Ongoing work on areas including polymer design, protein labelling and microfluidic technologies will ensure continued progress on improving resolution and throughput, providing deeper understanding of this most important group of targets. |*Nuclear Magnetic Resonance, Biomolecular[MESH] |Lipid Bilayers/*chemistry[MESH] |Membrane Lipids/*chemistry[MESH] |Membrane Proteins/*chemistry[MESH]Structure and function of proteins in membranes and nanodiscs (epmc).pdf DeepDyve Pubget Overpricing