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10.1080/14760584.2020.1800463

http://scihub22266oqcxt.onion/10.1080/14760584.2020.1800463
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suck abstract from ncbi


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pmid32838605      Expert+Rev+Vaccines 2020 ; 19 (8): 691-698
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  • Vaccination against SARS-CoV-2 and disease enhancement - knowns and unknowns #MMPMID32838605
  • Zellweger RM; Wartel TA; Marks F; Song M; Kim JH
  • Expert Rev Vaccines 2020[Aug]; 19 (8): 691-698 PMID32838605show ga
  • INTRODUCTION: The world is currently fighting a COVID-19 pandemic, perhaps the most disruptive infectious disease outbreak since the 1918 Spanish influenza. Governments have taken drastic measures to curb the spread of SARS-CoV-2, and the development of safe and efficacious vaccine candidates is being accelerated. The possibility of vaccine-mediated disease enhancement with coronavirus vaccines has been flagged as a potential safety concern, and, despite the urgent need, should be thoroughly assessed as vaccines against SARS-CoV-2 are being tested. AREA COVERED: We review the in vivo evidence suggesting a theoretical risk of disease enhancement after vaccination with SARS-CoV and MERS-CoV vaccine candidates. We also identify knowledge gaps that need to be filled to maximize the chance of developing a safe vaccine and minimize the risk of encountering disease enhancement in vaccinated individuals after exposure to SARS-CoV-2. EXPERT OPINION: We compile and propose avenues to investigate the risk of vaccine-mediated disease enhancement both during pre-clinical and early clinical development. While the pressing need for a vaccine against COVID-19 (and future epidemic coronaviruses) cannot be ignored, we advocate to keep safety at the center of the debate. Protecting individuals with effective and safe vaccines should be a priority, even during extraordinary times like the COVID-19 pandemic.
  • |Animals[MESH]
  • |Betacoronavirus/*immunology[MESH]
  • |COVID-19[MESH]
  • |COVID-19 Vaccines[MESH]
  • |Coronavirus Infections/epidemiology/immunology/*prevention & control[MESH]
  • |Humans[MESH]
  • |Pandemics/*prevention & control[MESH]
  • |Pneumonia, Viral/epidemiology/immunology/*prevention & control[MESH]
  • |SARS-CoV-2[MESH]
  • |Vaccination/adverse effects/methods[MESH]


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