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10.1016/j.medj.2020.06.008

http://scihub22266oqcxt.onion/10.1016/j.medj.2020.06.008
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32838361!7362813!32838361
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suck abstract from ncbi

pmid32838361      Med 2020 ; 1 (1): 43-65
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  • Investigating Ketone Bodies as Immunometabolic Countermeasures against Respiratory Viral Infections #MMPMID32838361
  • Stubbs BJ; Koutnik AP; Goldberg EL; Upadhyay V; Turnbaugh PJ; Verdin E; Newman JC
  • Med 2020[Dec]; 1 (1): 43-65 PMID32838361show ga
  • Respiratory viral infections remain a scourge, with seasonal influenza infecting millions and killing many thousands annually and viral pandemics, such as COVID-19, recurring every decade. Age, cardiovascular disease, and diabetes mellitus are risk factors for severe disease and death from viral infection. Immunometabolic therapies for these populations hold promise to reduce the risks of death and disability. Such interventions have pleiotropic effects that might not only target the virus itself but also enhance supportive care to reduce cardiopulmonary complications, improve cognitive resilience, and facilitate functional recovery. Ketone bodies are endogenous metabolites that maintain cellular energy but also feature drug-like signaling activities that affect immune activity, metabolism, and epigenetics. Here, we provide an overview of ketone body biology relevant to respiratory viral infection, focusing on influenza A and severe acute respiratory syndrome (SARS)-CoV-2, and discuss the opportunities, risks, and research gaps in the study of exogenous ketone bodies as novel immunometabolic interventions in these diseases.
  • |*COVID-19[MESH]
  • |*Influenza, Human/prevention & control[MESH]
  • |Humans[MESH]
  • |Ketone Bodies[MESH]
  • |Pandemics/prevention & control[MESH]


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