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10.1016/j.xcrm.2020.100078 http://scihub22266oqcxt.onion/10.1016/j.xcrm.2020.100078 32838342!7405891!32838342     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Cell+Rep+Med 2020 ; 1 (5): 100078 Nephropedia Template TP {{tp|p=32838342|t=2020. Systems-Level Immunomonitoring from Acute to Recovery Phase of Severe COVID-19 |pdf=|usr=}}{{32838342}} gab.com Text Systems-Level Immunomonitoring from Acute to Recovery Phase of Severe COVID-19 JO: Cell Rep Med http://www.kidney.de/pget.php?&tw=1&pmid=32838342 #FOAvip Severe disease of SARS-CoV-2 is characterized by vigorous inflammatory responses in the lung, often with a sudden onset after 5-7 days of stable disease. Efforts to modulate this hyperinflammation and the associated acute respiratory distress syndrome rely on the unraveling of the immune cell interactions and cytokines that drive such responses. Given that every patient is captured at different stages of infection, longitudinal monitoring of the immune response is critical and systems-level analyses are required to capture cellular interactions. Here, we report on a systems-level blood immunomonitoring study of 37 adult patients diagnosed with COVID-19 and followed with up to 14 blood samples from acute to recovery phases of the disease. We describe an IFNgamma-eosinophil axis activated before lung hyperinflammation and changes in cell-cell co-regulation during different stages of the disease. We also map an immune trajectory during recovery that is shared among patients with severe COVID-19. Twit Text FOAVip Systems-Level Immunomonitoring from Acute to Recovery Phase of Severe COVID-19 ????Cell Rep Med http://www.kidney.de/pget.php?&tw=1&pmid=32838342 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=32838342 #FOAvip English Wikipedia <ref>{{Cite pmid|32838342}}</ref> Systems-Level Immunomonitoring from Acute to Recovery Phase of Severe COVID-19 #MMPMID32838342 Rodriguez L; Pekkarinen PT; Lakshmikanth T; Tan Z; Consiglio CR; Pou C; Chen Y; Mugabo CH; Nguyen NA; Nowlan K; Strandin T; Levanov L; Mikes J; Wang J; Kantele A; Hepojoki J; Vapalahti O; Heinonen S; Kekalainen E; Brodin P Cell Rep Med 2020[Aug]; 1 (5): 100078 PMID32838342show ga Severe disease of SARS-CoV-2 is characterized by vigorous inflammatory responses in the lung, often with a sudden onset after 5-7 days of stable disease. Efforts to modulate this hyperinflammation and the associated acute respiratory distress syndrome rely on the unraveling of the immune cell interactions and cytokines that drive such responses. Given that every patient is captured at different stages of infection, longitudinal monitoring of the immune response is critical and systems-level analyses are required to capture cellular interactions. Here, we report on a systems-level blood immunomonitoring study of 37 adult patients diagnosed with COVID-19 and followed with up to 14 blood samples from acute to recovery phases of the disease. We describe an IFNgamma-eosinophil axis activated before lung hyperinflammation and changes in cell-cell co-regulation during different stages of the disease. We also map an immune trajectory during recovery that is shared among patients with severe COVID-19. |Adaptive Immunity[MESH] |Adult[MESH] |Basophils/metabolism[MESH] |COVID-19/blood/*immunology[MESH] |Cell Communication[MESH] |Convalescence[MESH] |Eosinophils/metabolism[MESH] |Female[MESH] |Humans[MESH] |Inflammation[MESH] |Interferon-gamma/blood[MESH] |Interleukin-6/blood[MESH] |Longitudinal Studies[MESH] |Male[MESH] |SARS-CoV-2[MESH]Systems-Level Immunomonitoring from Acute to Recovery Phase of Severe (epmc).pdf DeepDyve Pubget Overpricing