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Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Cell+Rep+Med 2020 ; 1 (5): 100062 Nephropedia Template TP
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Point of Care Nucleic Acid Testing for SARS-CoV-2 in Hospitalized Patients: A Clinical Validation Trial and Implementation Study #MMPMID32838340
Collier DA; Assennato SM; Warne B; Sithole N; Sharrocks K; Ritchie A; Ravji P; Routledge M; Sparkes D; Skittrall J; Smielewska A; Ramsey I; Goel N; Curran M; Enoch D; Tassell R; Lineham M; Vaghela D; Leong C; Mok HP; Bradley J; Smith KGC; Mendoza V; Demiris N; Besser M; Dougan G; Lehner PJ; Siedner MJ; Zhang H; Waddington CS; Lee H; Gupta RK
Cell Rep Med 2020[Aug]; 1 (5): 100062 PMID32838340show ga
There is an urgent need for rapid SARS-CoV-2 testing in hospitals to limit nosocomial spread. We report an evaluation of point of care (POC) nucleic acid amplification testing (NAAT) in 149 participants with parallel combined nasal and throat swabbing for POC versus standard lab RT-PCR testing. Median time to result is 2.6 (IQR 2.3-4.8) versus 26.4 h (IQR 21.4-31.4, p < 0.001), with 32 (21.5%) positive and 117 (78.5%) negative. Cohen's kappa correlation between tests is 0.96 (95% CI 0.91-1.00). When comparing nearly 1,000 tests pre- and post-implementation, the median time to definitive bed placement from admission is 23.4 (8.6-41.9) versus 17.1 h (9.0-28.8), p = 0.02. Mean length of stay on COVID-19 "holding" wards is 58.5 versus 29.9 h (p < 0.001). POC testing increases isolation room availability, avoids bed closures, allows discharge to care homes, and expedites access to hospital procedures. POC testing could mitigate the impact of COVID-19 on hospital systems.