Use my Search Websuite to scan PubMed, PMCentral, Journal Hosts and Journal Archives, FullText. Kick-your-searchterm to multiple Engines kick-your-query now !>

A dictionary by aggregated review articles of nephrology, medicine and the life sciences Your one-stop-run pathway from word to the immediate pdf of peer-reviewed on-topic knowledge.

10.1016/j.tice.2020.101402 http://scihub22266oqcxt.onion/10.1016/j.tice.2020.101402 32835935!ä!32835935 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 278.79999999999995 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Tissue+Cell 2020 ; 67 (ä): 101402 Nephropedia Template TP {{tp|p=32835935|t=2020. HIF-1alpha induces hypoxic apoptosis of MLO-Y4 osteocytes via JNK/caspase-3 pathway and the apoptotic-osteocyte-mediated osteoclastogenesis in vitro |pdf=|usr=}}{{32835935}} gab.com Text HIF-1alpha induces hypoxic apoptosis of MLO-Y4 osteocytes via JNK/caspase-3 pathway and the apoptotic-osteocyte-mediated osteoclastogenesis in vitro JO: Tissue Cell http://www.kidney.de/pget.php?&tw=1&pmid=32835935 #FOAvip Apoptotic osteocytes were found in the hypoxic bone microenvironment in osteoporosis, osteotomy, orthodontic tooth movement and periodontitis, and played a key role in bone remolding and the differentiation of osteoclasts. Hypoxia inducible factor-1alpha(HIF-1alpha), as a transcription factor under hypoxic conditions, has been confirmed to participate in cell apoptosis. However, the effect of HIF-1alpha on osteocytes apoptosis and the osteocyte-mediated osteoclast formation remains elusive. Here, we hypothesized that HIF-1alpha was involved in osteocytes apoptosis. Our results showed that CoCl(2) increased the MLO-Y4 cells apoptosis by upregulating the proapoptotic gene expression of caspase-3. Moreover, siRNA-mediated knockdown of HIF-1alpha decreased the phosphorylation by JNK and the activation of caspase-3 to inhibit the cell apoptosis in MLO-Y4. Furthermore, SP600125, an inhibitor of JNK, reversed CoCl(2)-induced the increased apoptosis of MLO-Y4 cells in term of reducing the expression of caspase-3. These findings revealed that HIF-1alpha served as a pro-apoptotic factor in the apoptosis of MLO-Y4 cells cultured with CoCl(2), by activating the JNK/caspase-3 signaling pathway. Besides, the osteocyte-mediated osteoclastogenesis was reduced with the decline of the expression of HIF-1alpha and caspase-3 in MLO-Y4 cells. Our study provided an idea for a more comprehensive understanding of HIF-1alpha and the process of bone remodeling. Twit Text FOAVip HIF-1alpha induces hypoxic apoptosis of MLO-Y4 osteocytes via JNK/caspase-3 pathway and the apoptotic-osteocyte-mediated osteoclastogenesis in vitro ????Tissue Cell http://www.kidney.de/pget.php?&tw=1&pmid=32835935 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=32835935 #FOAvip English Wikipedia <ref>{{Cite pmid|32835935}}</ref> HIF-1alpha induces hypoxic apoptosis of MLO-Y4 osteocytes via JNK/caspase-3 pathway and the apoptotic-osteocyte-mediated osteoclastogenesis in vitro #MMPMID32835935 Song X; Tang Y; Zhu J; Tian Y; Song Z; Hu X; Hong C; Cai Y; Kang F Tissue Cell 2020[Dec]; 67 (ä): 101402 PMID32835935show ga Apoptotic osteocytes were found in the hypoxic bone microenvironment in osteoporosis, osteotomy, orthodontic tooth movement and periodontitis, and played a key role in bone remolding and the differentiation of osteoclasts. Hypoxia inducible factor-1alpha(HIF-1alpha), as a transcription factor under hypoxic conditions, has been confirmed to participate in cell apoptosis. However, the effect of HIF-1alpha on osteocytes apoptosis and the osteocyte-mediated osteoclast formation remains elusive. Here, we hypothesized that HIF-1alpha was involved in osteocytes apoptosis. Our results showed that CoCl(2) increased the MLO-Y4 cells apoptosis by upregulating the proapoptotic gene expression of caspase-3. Moreover, siRNA-mediated knockdown of HIF-1alpha decreased the phosphorylation by JNK and the activation of caspase-3 to inhibit the cell apoptosis in MLO-Y4. Furthermore, SP600125, an inhibitor of JNK, reversed CoCl(2)-induced the increased apoptosis of MLO-Y4 cells in term of reducing the expression of caspase-3. These findings revealed that HIF-1alpha served as a pro-apoptotic factor in the apoptosis of MLO-Y4 cells cultured with CoCl(2), by activating the JNK/caspase-3 signaling pathway. Besides, the osteocyte-mediated osteoclastogenesis was reduced with the decline of the expression of HIF-1alpha and caspase-3 in MLO-Y4 cells. Our study provided an idea for a more comprehensive understanding of HIF-1alpha and the process of bone remodeling. |*Apoptosis/drug effects[MESH] |*MAP Kinase Signaling System/drug effects[MESH] |*Osteogenesis/drug effects/genetics[MESH] |Animals[MESH] |Caspase 3/*metabolism[MESH] |Cell Differentiation/drug effects[MESH] |Cell Hypoxia/drug effects/genetics[MESH] |Cell Line[MESH] |Cobalt/pharmacology[MESH] |Hypoxia-Inducible Factor 1, alpha Subunit/genetics/*metabolism[MESH] |Mice[MESH] |Osteocytes/drug effects/*metabolism[MESH] |RNA, Messenger/genetics/metabolism[MESH] |RNA, Small Interfering/metabolism[MESH]HIF-1alpha induces hypoxic apoptosis of MLO-Y4 osteocytes via JNK/casp(epmc).pdf DeepDyve Pubget Overpricing