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Sex differences underlying preexisting cardiovascular disease and cardiovascular injury in COVID-19 #MMPMID32835666
Medzikovic L; Cunningham CM; Li M; Amjedi M; Hong J; Ruffenach G; Eghbali M
J Mol Cell Cardiol 2020[Nov]; 148 (?): 25-33 PMID32835666show ga
The novel 2019 coronavirus disease (COVID-19), resulting from severe acute respiratory syndrome coronarvirus-2 (SARS-CoV-2) infection, typically leads to respiratory failure in severe cases; however, cardiovascular injury is reported to contribute to a substantial proportion of COVID-19 deaths. Preexisting cardiovascular disease (CVD) is among the most common risk factors for hospitalization and death in COVID-19 patients, and the pathogenic mechanisms of COVID-19 disease progression itself may promote the development of cardiovascular injury, increasing risk of in-hospital death. Sex differences in COVID-19 are becoming more apparent as mounting data indicate that males seem to be disproportionately at risk of severe COVID-19 outcome due to preexisting CVD and COVID-19-related cardiovascular injury. In this review, we will provide a basic science perspective on current clinical observations in this rapidly evolving field and discuss the interplay sex differences, preexisting CVD and COVID-19-related cardiac injury.
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J+Mol+Cell+Cardiol 2020 ; 148 (?): 25-33
