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10.1016/j.obmed.2020.100281 http://scihub22266oqcxt.onion/10.1016/j.obmed.2020.100281 32835124!7362855!32835124     free     free     free Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 269.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Obes+Med 2020 ; 19 (ä): 100281 Nephropedia Template TP {{tp|p=32835124|t=2020. A multicenter consensus: A role of furin in the endothelial tropism in obese patients with COVID-19 infection |pdf=|usr=}}{{32835124}} gab.com Text A multicenter consensus: A role of furin in the endothelial tropism in obese patients with COVID-19 infection JO: Obes Med http://www.kidney.de/pget.php?&tw=1&pmid=32835124 #FOAvip Furin, a cleavage enzyme, is increasingly recognized in the pathogenesis of metabolic syndrome. Its cleavage action is an essential activation step for the endothelial pathogenicity of several viruses including SARS-CoV-2. This Furin-mediated endothelial tropism seems to underlie the multi-organ system involvement of COVID-19; which is a feature that was not recognized in the older versions of coronaviridae. Obese and diabetic patients, males, and the elderly, have increased serum levels of Furin, with its increased cellular activity; this might explain why these subgroups are at an increased risk of COVID-19 related complications and deaths. In contrast, smoking decreases cellular levels of Furin, this finding may be at the origin of the decreased severity of COVID-19 in smokers. Chinese herbal derived luteolin is suggested to be putative Furin inhibitor, with previous success against Dengue Fever. Additionally, Furin intracellular levels are largely dependent on concentration of intracellular ions, notably sodium, potassium, and magnesium. Consequently, the use of ion channel inhibitors, such as Calcium Channel blockers or Potassium Channel blockers, can prevent cellular transfection early in the course of the illness. Nicotine patches and Colchicine have also been suggested as potential therapies due to Furin mediated inhibition of COVID-19. Twit Text FOAVip A multicenter consensus: A role of furin in the endothelial tropism in obese patients with COVID-19 infection ????Obes Med http://www.kidney.de/pget.php?&tw=1&pmid=32835124 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=32835124 #FOAvip English Wikipedia <ref>{{Cite pmid|32835124}}</ref> A multicenter consensus: A role of furin in the endothelial tropism in obese patients with COVID-19 infection #MMPMID32835124 AbdelMassih AF; Ye J; Kamel A; Mishriky F; Ismail HA; Ragab HA; El Qadi L; Malak L; Abdu M; El-Husseiny M; Ashraf M; Hafez N; AlShehry N; El-Husseiny N; AbdelRaouf N; Shebl N; Hafez N; Youssef N; Afdal P; Hozaien R; Menshawey R; Saeed R; Fouda R Obes Med 2020[Sep]; 19 (ä): 100281 PMID32835124show ga Furin, a cleavage enzyme, is increasingly recognized in the pathogenesis of metabolic syndrome. Its cleavage action is an essential activation step for the endothelial pathogenicity of several viruses including SARS-CoV-2. This Furin-mediated endothelial tropism seems to underlie the multi-organ system involvement of COVID-19; which is a feature that was not recognized in the older versions of coronaviridae. Obese and diabetic patients, males, and the elderly, have increased serum levels of Furin, with its increased cellular activity; this might explain why these subgroups are at an increased risk of COVID-19 related complications and deaths. In contrast, smoking decreases cellular levels of Furin, this finding may be at the origin of the decreased severity of COVID-19 in smokers. Chinese herbal derived luteolin is suggested to be putative Furin inhibitor, with previous success against Dengue Fever. Additionally, Furin intracellular levels are largely dependent on concentration of intracellular ions, notably sodium, potassium, and magnesium. Consequently, the use of ion channel inhibitors, such as Calcium Channel blockers or Potassium Channel blockers, can prevent cellular transfection early in the course of the illness. Nicotine patches and Colchicine have also been suggested as potential therapies due to Furin mediated inhibition of COVID-19. äA multicenter consensus: A role of furin in the endothelial tropism in(epmc).pdf DeepDyve Pubget Overpricing