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Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Trends+Analyt+Chem 2020 ; 130 (ä): 115984 Nephropedia Template TP
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The vision of point-of-care PCR tests for the COVID-19 pandemic and beyond #MMPMID32834243
Zhu H; Zhang H; Ni S; Korabecna M; Yobas L; Neuzil P
Trends Analyt Chem 2020[Sep]; 130 (ä): 115984 PMID32834243show ga
Infectious diseases, such as the most recent case of coronavirus disease 2019, have brought the prospect of point-of-care (POC) diagnostic tests into the spotlight. A rapid, accurate, low-cost, and easy-to-use test in the field could stop epidemics before they develop into full-blown pandemics. Unfortunately, despite all the advances, it still does not exist. Here, we critically review the limited number of prototypes demonstrated to date that is based on a polymerase chain reaction (PCR) and has come close to fulfill this vision. We summarize the requirements for the POC-PCR tests and then go on to discuss the PCR product-detection methods, the integration of their functional components, the potential applications, and other practical issues related to the implementation of lab-on-a-chip technologies. We conclude our review with a discussion of the latest findings on nucleic acid-based diagnosis.