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10.1172/JCI140965 http://scihub22266oqcxt.onion/10.1172/JCI140965 32833687!7685725!32833687     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       J+Clin+Invest 2020 ; 130 (12): 6477-6489 Nephropedia Template TP {{tp|p=32833687|t=2020. SARS-CoV-2-specific T cell responses and correlations with COVID-19 patient predisposition |pdf=|usr=}}{{32833687}} gab.com Text SARS-CoV-2-specific T cell responses and correlations with COVID-19 patient predisposition JO: J Clin Invest http://www.kidney.de/pget.php?&tw=1&pmid=32833687 #FOAvip Coronavirus disease 2019 (COVID-19) has emerged as a global pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). So far, viral targets of cellular immunity and factors determining successful mounting of T cell responses are poorly defined. We therefore analyzed cellular responses to membrane, nucleocapsid, and spike proteins in individuals suffering from moderate or severe infection and in individuals who recovered from mild disease. We demonstrate that the CoV-2-specific CD4+ T helper cell response is directed against all 3 proteins with comparable magnitude, ex vivo proliferation, and portions of responding patients. However, individuals who died were more likely to have not mounted a cellular response to the proteins. Higher patient age and comorbidity index correlated with increased frequencies of CoV-2-specific CD4+ T cells, harboring higher portions of IL-2-secreting, but lower portions of IFN-gamma-secreting, cells. Diminished frequencies of membrane protein-reactive IFN-gamma+ T cells were particularly associated with higher acute physiology and chronic health evaluation II scores in patients admitted to intensive care. CoV-2-specific T cells exhibited elevated PD-1 expression in patients with active disease as compared with those individuals who recovered from previous mild disease. In summary, our data suggest a link between individual patient predisposition with respect to age and comorbidity and impairment of CoV-2-specific Th1-type cellular immunity, thereby supporting a concept of altered T cell function in at-risk patients. Twit Text FOAVip SARS-CoV-2-specific T cell responses and correlations with COVID-19 patient predisposition ????J Clin Invest http://www.kidney.de/pget.php?&tw=1&pmid=32833687 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=32833687 #FOAvip English Wikipedia <ref>{{Cite pmid|32833687}}</ref> SARS-CoV-2-specific T cell responses and correlations with COVID-19 patient predisposition #MMPMID32833687 Sattler A; Angermair S; Stockmann H; Heim KM; Khadzhynov D; Treskatsch S; Halleck F; Kreis ME; Kotsch K J Clin Invest 2020[Dec]; 130 (12): 6477-6489 PMID32833687show ga Coronavirus disease 2019 (COVID-19) has emerged as a global pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). So far, viral targets of cellular immunity and factors determining successful mounting of T cell responses are poorly defined. We therefore analyzed cellular responses to membrane, nucleocapsid, and spike proteins in individuals suffering from moderate or severe infection and in individuals who recovered from mild disease. We demonstrate that the CoV-2-specific CD4+ T helper cell response is directed against all 3 proteins with comparable magnitude, ex vivo proliferation, and portions of responding patients. However, individuals who died were more likely to have not mounted a cellular response to the proteins. Higher patient age and comorbidity index correlated with increased frequencies of CoV-2-specific CD4+ T cells, harboring higher portions of IL-2-secreting, but lower portions of IFN-gamma-secreting, cells. Diminished frequencies of membrane protein-reactive IFN-gamma+ T cells were particularly associated with higher acute physiology and chronic health evaluation II scores in patients admitted to intensive care. CoV-2-specific T cells exhibited elevated PD-1 expression in patients with active disease as compared with those individuals who recovered from previous mild disease. In summary, our data suggest a link between individual patient predisposition with respect to age and comorbidity and impairment of CoV-2-specific Th1-type cellular immunity, thereby supporting a concept of altered T cell function in at-risk patients. |Adult[MESH] |Age Factors[MESH] |Aged[MESH] |Aged, 80 and over[MESH] |COVID-19/*immunology/pathology[MESH] |Disease Susceptibility[MESH] |Female[MESH] |Humans[MESH] |Interferon-gamma/*immunology[MESH] |Interleukin-2/*immunology[MESH] |Male[MESH] |Middle Aged[MESH] |Programmed Cell Death 1 Receptor/*immunology[MESH] |SARS-CoV-2/*immunology[MESH] |Severity of Illness Index[MESH]SARS-CoV-2-specific T cell responses and correlations with COVID-19 pa(epmc).pdf DeepDyve Pubget Overpricing