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10.1515/cclm-2020-1062 http://scihub22266oqcxt.onion/10.1515/cclm-2020-1062 32829312!ä!32829312 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Clin+Chem+Lab+Med 2020 ; 58 (12): 1979-1981 Nephropedia Template TP {{tp|p=32829312|t=2020. Lactate dehydrogenase: an old enzyme reborn as a COVID-19 marker (and not only) |pdf=|usr=}}{{32829312}} gab.com Text Lactate dehydrogenase: an old enzyme reborn as a COVID-19 marker (and not only) JO: Clin Chem Lab Med http://www.kidney.de/pget.php?&tw=1&pmid=32829312 #FOAvip Background Historically, the lactate dehydrogenase (LDH) measurement was introduced into Laboratory Medicine as component (together with creatine kinase (CK) and aspartate aminotransferase) of the classical enzyme triad employed for the diagnosis of myocardial infarction, which was subsequently replaced by CK-MB, and more recently by cardiac troponins. Afterwards, for many years, the clinical application of serum LDH measurement has been limited to the evaluation of anemias and to as a rough prognostic tool for certain tumors. Content In the last few years, significant changes have happened. First, the test has been confirmed as a robust predictor of poor outcomes in many neoplastic conditions. Furthermore, in the Revised International Staging System adopted in the 2015 by the International Myeloma Working Group, LDH acts as determinant of disease biology in differentiating myeloma stages. Finally, in the last few months, LDH is definitively reborn given its proven significant contribution in defining the COVID-19 severity. Conclusions This increased clinical role calls for an improvement of LDH assay standardization through the implementation of traceability of results of clinical samples to the available reference measurement system. Twit Text FOAVip Lactate dehydrogenase: an old enzyme reborn as a COVID-19 marker (and not only) ????Clin Chem Lab Med http://www.kidney.de/pget.php?&tw=1&pmid=32829312 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=32829312 #FOAvip English Wikipedia <ref>{{Cite pmid|32829312}}</ref> Lactate dehydrogenase: an old enzyme reborn as a COVID-19 marker (and not only) #MMPMID32829312 Panteghini M Clin Chem Lab Med 2020[Aug]; 58 (12): 1979-1981 PMID32829312show ga Background Historically, the lactate dehydrogenase (LDH) measurement was introduced into Laboratory Medicine as component (together with creatine kinase (CK) and aspartate aminotransferase) of the classical enzyme triad employed for the diagnosis of myocardial infarction, which was subsequently replaced by CK-MB, and more recently by cardiac troponins. Afterwards, for many years, the clinical application of serum LDH measurement has been limited to the evaluation of anemias and to as a rough prognostic tool for certain tumors. Content In the last few years, significant changes have happened. First, the test has been confirmed as a robust predictor of poor outcomes in many neoplastic conditions. Furthermore, in the Revised International Staging System adopted in the 2015 by the International Myeloma Working Group, LDH acts as determinant of disease biology in differentiating myeloma stages. Finally, in the last few months, LDH is definitively reborn given its proven significant contribution in defining the COVID-19 severity. Conclusions This increased clinical role calls for an improvement of LDH assay standardization through the implementation of traceability of results of clinical samples to the available reference measurement system. |Biomarkers/blood[MESH] |COVID-19[MESH] |Coronavirus Infections/*blood/diagnosis/enzymology/epidemiology[MESH] |Disease-Free Survival[MESH] |Humans[MESH] |L-Lactate Dehydrogenase/*blood[MESH] |Pandemics[MESH]Lactate dehydrogenase: an old enzyme reborn as a COVID-19 marker (and (epmc).pdf DeepDyve Pubget Overpricing