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Host Polymorphisms May Impact SARS-CoV-2 Infectivity #MMPMID32828550
Brest P; Refae S; Mograbi B; Hofman P; Milano G
Trends Genet 2020[Nov]; 36 (11): 813-815 PMID32828550show ga
Based on a broad public database compilation, we support the hypothesis that germinal polymorphisms may regulate the expression of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) cellular target itself and proteases controlling the process of its shedding or, conversely, its internalization. Consequently, a genetic influence on individual susceptibility to coronavirus disease 2019 (COVID-19) infection is strongly suspected.