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10.1016/j.jcv.2020.104592 http://scihub22266oqcxt.onion/10.1016/j.jcv.2020.104592 32827898!7427616!32827898     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=32827898&cmd=llinks): Failed to open stream: HTTP request failed! 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Performance of a qualitative rapid chromatographic immunoassay to diagnose COVID-19 in patients in a middle-income country |pdf=|usr=}}{{32827898}} gab.com Text Performance of a qualitative rapid chromatographic immunoassay to diagnose COVID-19 in patients in a middle-income country JO: J Clin Virol http://www.kidney.de/pget.php?&tw=1&pmid=32827898 #FOAvip OBJECTIVES: We evaluated a rapid chromatographic immunoassay (IgG/IgM antibodies) and an ELISA assay to diagnose COVID-19 in patient sat two Brazilian hospitals. METHODS: A total of 122 subjects with COVID-19 were included: 106 SARS-COV-2 RT-PCR-positive patients and 16 RT-PCR-negative patients with symptoms and chest computed tomography (CT) consistent with COVID-19. Ninety-six historical blood donation samples were used as controls. Demographic and clinical characteristics were retrieved from electronic records. Sensitivity and specificity were calculated, as were their 95% binomial confidence intervals using the Clopper-Pearson method. All analyses were performed in R version 3.6.3. RESULTS: The sensitivity of the chromatographic immunoassay in all RT-PCR-positive patients, irrespective of the timing of symptom onset, was 85.8% (95% binomial CI 77.7% to 91.9%). This increased with time after symptom onset, and at >14 days was 94.9% (85.9% to 98.9%). The specificity was 100% (96.4% to 100%). 15/16 (94%) RT- PCR-negative cases tested positive. The most frequent comorbidities were hypertension and diabetes mellitus and the most frequent symptoms were fever, cough, and dyspnea. All RT-PCR-negative patients had pneumonia. The most frequent thoracic CT findings were ground glass changes (n?=?11, 68%), which were bilateral in 9 (56%) patients, and diffuse reticulonodular infiltrates (n?=?5, 31%). CONCLUSIONS: The COVID-19 rapid chromatographic immunoassay evaluated in this study had a high sensitivity and specificity using plasma, particularly after 14 days from symptom onset. ELISA and qualitative rapid chromatographic immunoassays can be used for the diagnosis of RT-PCR-negative patients. Twit Text FOAVip Performance of a qualitative rapid chromatographic immunoassay to diagnose COVID-19 in patients in a middle-income country ????J Clin Virol http://www.kidney.de/pget.php?&tw=1&pmid=32827898 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=32827898 #FOAvip English Wikipedia <ref>{{Cite pmid|32827898}}</ref> Performance of a qualitative rapid chromatographic immunoassay to diagnose COVID-19 in patients in a middle-income country #MMPMID32827898 Costa SF; Buss L; Espinoza EPS; Vieira JM Jr; de Oliveira da Silva LC; de Souza RM; Neto LP; Porto APM; Lazari C; Dos Santos VA; da Silva Duarte A; Nastri AC; da Costa Leite GF; Manuli E; de Oliveira MS; Zampelli DB; Pastore L Junior; Segurado AC; Levin AS; Sabino E J Clin Virol 2020[Oct]; 131 (ä): 104592 PMID32827898show ga OBJECTIVES: We evaluated a rapid chromatographic immunoassay (IgG/IgM antibodies) and an ELISA assay to diagnose COVID-19 in patient sat two Brazilian hospitals. METHODS: A total of 122 subjects with COVID-19 were included: 106 SARS-COV-2 RT-PCR-positive patients and 16 RT-PCR-negative patients with symptoms and chest computed tomography (CT) consistent with COVID-19. Ninety-six historical blood donation samples were used as controls. Demographic and clinical characteristics were retrieved from electronic records. Sensitivity and specificity were calculated, as were their 95% binomial confidence intervals using the Clopper-Pearson method. All analyses were performed in R version 3.6.3. RESULTS: The sensitivity of the chromatographic immunoassay in all RT-PCR-positive patients, irrespective of the timing of symptom onset, was 85.8% (95% binomial CI 77.7% to 91.9%). This increased with time after symptom onset, and at >14 days was 94.9% (85.9% to 98.9%). The specificity was 100% (96.4% to 100%). 15/16 (94%) RT- PCR-negative cases tested positive. The most frequent comorbidities were hypertension and diabetes mellitus and the most frequent symptoms were fever, cough, and dyspnea. All RT-PCR-negative patients had pneumonia. The most frequent thoracic CT findings were ground glass changes (n?=?11, 68%), which were bilateral in 9 (56%) patients, and diffuse reticulonodular infiltrates (n?=?5, 31%). CONCLUSIONS: The COVID-19 rapid chromatographic immunoassay evaluated in this study had a high sensitivity and specificity using plasma, particularly after 14 days from symptom onset. ELISA and qualitative rapid chromatographic immunoassays can be used for the diagnosis of RT-PCR-negative patients. |*Chromatography[MESH] |*Immunoassay[MESH] |Adult[MESH] |Aged[MESH] |Aged, 80 and over[MESH] |Antibodies, Viral/*blood[MESH] |Betacoronavirus[MESH] |Brazil[MESH] |COVID-19[MESH] |COVID-19 Testing[MESH] |Clinical Laboratory Techniques[MESH] |Coronavirus Infections/*diagnosis/immunology[MESH] |Female[MESH] |Hospitalization/statistics & numerical data[MESH] |Humans[MESH] |Immunoglobulin G/blood[MESH] |Male[MESH] |Middle Aged[MESH] |Pandemics[MESH] |Pneumonia, Viral/*diagnosis/immunology[MESH] |Prospective Studies[MESH] |SARS-CoV-2[MESH] |Sensitivity and Specificity[MESH]Performance of a qualitative rapid chromatographic immunoassay to diag(epmc).pdf DeepDyve Pubget Overpricing