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10.1111/tan.14047

http://scihub22266oqcxt.onion/10.1111/tan.14047
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32827207!7461491!32827207
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suck abstract from ncbi


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pmid32827207      HLA 2020 ; 96 (5): 610-614
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  • HLA allele frequencies and susceptibility to COVID-19 in a group of 99 Italian patients #MMPMID32827207
  • Novelli A; Andreani M; Biancolella M; Liberatoscioli L; Passarelli C; Colona VL; Rogliani P; Leonardis F; Campana A; Carsetti R; Andreoni M; Bernardini S; Novelli G; Locatelli F
  • HLA 2020[Nov]; 96 (5): 610-614 PMID32827207show ga
  • With the aim to individuate alleles that may reflect a higher susceptibility to the disease, in the present study we analyzed the HLA allele frequency distribution in a group of 99 Italian patients affected by a severe or extremely severe form of COVID-19. After the application of Bonferroni's correction for multiple tests, a significant association was found for HLA-DRB1*15:01, -DQB1*06:02 and -B*27:07, after comparing the results to a reference group of 1017 Italian individuals, previously typed in our laboratory. The increased frequencies observed may contribute to identify potential markers of susceptibility to the disease, although controversial results on the role of single HLA alleles in COVID-19 patients have been recently reported.
  • |*Genetic Predisposition to Disease[MESH]
  • |*Haplotypes[MESH]
  • |Adolescent[MESH]
  • |Adult[MESH]
  • |Aged[MESH]
  • |Aged, 80 and over[MESH]
  • |Alleles[MESH]
  • |Betacoronavirus/*isolation & purification[MESH]
  • |COVID-19[MESH]
  • |Child[MESH]
  • |Child, Preschool[MESH]
  • |Coronavirus Infections/*epidemiology/genetics/transmission/virology[MESH]
  • |Female[MESH]
  • |Gene Frequency[MESH]
  • |HLA Antigens/classification/*genetics[MESH]
  • |Humans[MESH]
  • |Italy/epidemiology[MESH]
  • |Male[MESH]
  • |Middle Aged[MESH]
  • |Pandemics[MESH]
  • |Pneumonia, Viral/*epidemiology/genetics/transmission/virology[MESH]
  • |SARS-CoV-2[MESH]


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