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10.1038/s41467-020-18058-8 http://scihub22266oqcxt.onion/10.1038/s41467-020-18058-8 32826914!7442812!32826914     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Nat+Commun 2020 ; 11 (1): 4198 Nephropedia Template TP {{tp|p=32826914|t=2020. A cross-reactive human IgA monoclonal antibody blocks SARS-CoV-2 spike-ACE2 interaction |pdf=|usr=}}{{32826914}} gab.com Text A cross-reactive human IgA monoclonal antibody blocks SARS-CoV-2 spike-ACE2 interaction JO: Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=32826914 #FOAvip COVID-19 caused by SARS-CoV-2 has become a global pandemic requiring the development of interventions for the prevention or treatment to curtail mortality and morbidity. No vaccine to boost mucosal immunity, or as a therapeutic, has yet been developed to SARS-CoV-2. In this study, we discover and characterize a cross-reactive human IgA monoclonal antibody, MAb362. MAb362 binds to both SARS-CoV and SARS-CoV-2 spike proteins and competitively blocks ACE2 receptor binding, by overlapping the ACE2 structural binding epitope. Furthermore, MAb362 IgA neutralizes both pseudotyped SARS-CoV and SARS-CoV-2 in 293 cells expressing ACE2. When converted to secretory IgA, MAb326 also neutralizes authentic SARS-CoV-2 virus while the IgG isotype shows no neutralization. Our results suggest that SARS-CoV-2 specific IgA antibodies, such as MAb362, may provide effective immunity against SARS-CoV-2 by inducing mucosal immunity within the respiratory system, a potentially critical feature of an effective vaccine. Twit Text FOAVip A cross-reactive human IgA monoclonal antibody blocks SARS-CoV-2 spike-ACE2 interaction ????Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=32826914 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=32826914 #FOAvip English Wikipedia <ref>{{Cite pmid|32826914}}</ref> A cross-reactive human IgA monoclonal antibody blocks SARS-CoV-2 spike-ACE2 interaction #MMPMID32826914 Ejemel M; Li Q; Hou S; Schiller ZA; Tree JA; Wallace A; Amcheslavsky A; Kurt Yilmaz N; Buttigieg KR; Elmore MJ; Godwin K; Coombes N; Toomey JR; Schneider R; Ramchetty AS; Close BJ; Chen DY; Conway HL; Saeed M; Ganesa C; Carroll MW; Cavacini LA; Klempner MS; Schiffer CA; Wang Y Nat Commun 2020[Aug]; 11 (1): 4198 PMID32826914show ga COVID-19 caused by SARS-CoV-2 has become a global pandemic requiring the development of interventions for the prevention or treatment to curtail mortality and morbidity. No vaccine to boost mucosal immunity, or as a therapeutic, has yet been developed to SARS-CoV-2. In this study, we discover and characterize a cross-reactive human IgA monoclonal antibody, MAb362. MAb362 binds to both SARS-CoV and SARS-CoV-2 spike proteins and competitively blocks ACE2 receptor binding, by overlapping the ACE2 structural binding epitope. Furthermore, MAb362 IgA neutralizes both pseudotyped SARS-CoV and SARS-CoV-2 in 293 cells expressing ACE2. When converted to secretory IgA, MAb326 also neutralizes authentic SARS-CoV-2 virus while the IgG isotype shows no neutralization. Our results suggest that SARS-CoV-2 specific IgA antibodies, such as MAb362, may provide effective immunity against SARS-CoV-2 by inducing mucosal immunity within the respiratory system, a potentially critical feature of an effective vaccine. |Angiotensin-Converting Enzyme 2[MESH] |Animals[MESH] |Antibodies, Monoclonal/*immunology/metabolism[MESH] |Antibodies, Neutralizing/*immunology/metabolism[MESH] |Betacoronavirus/*immunology[MESH] |Chlorocebus aethiops[MESH] |Cross Reactions[MESH] |Epitopes[MESH] |HEK293 Cells[MESH] |Humans[MESH] |Immunoglobulin A, Secretory/immunology/metabolism[MESH] |Immunoglobulin A/*immunology/metabolism[MESH] |Immunoglobulin G/immunology/metabolism[MESH] |Models, Molecular[MESH] |Mutation[MESH] |Peptidyl-Dipeptidase A/*metabolism[MESH] |Protein Binding[MESH] |Protein Interaction Domains and Motifs[MESH] |SARS-CoV-2[MESH] |Severe acute respiratory syndrome-related coronavirus/immunology[MESH] |Spike Glycoprotein, Coronavirus/chemistry/genetics/immunology/*metabolism[MESH]A cross-reactive human IgA monoclonal antibody blocks SARS-CoV-2 spike(epmc).pdf DeepDyve Pubget Overpricing