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10.1126/sciimmunol.abd6832 http://scihub22266oqcxt.onion/10.1126/sciimmunol.abd6832 32826343!7665314!32826343     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Sci+Immunol 2020 ; 5 (50): ä Nephropedia Template TP {{tp|p=32826343|t=2020. Natural killer cell immunotypes related to COVID-19 disease severity |pdf=|usr=}}{{32826343}} gab.com Text Natural killer cell immunotypes related to COVID-19 disease severity JO: Sci Immunol http://www.kidney.de/pget.php?&tw=1&pmid=32826343 #FOAvip Understanding innate immune responses in COVID-19 is important to decipher mechanisms of host responses and interpret disease pathogenesis. Natural killer (NK) cells are innate effector lymphocytes that respond to acute viral infections but might also contribute to immunopathology. Using 28-color flow cytometry, we here reveal strong NK cell activation across distinct subsets in peripheral blood of COVID-19 patients. This pattern was mirrored in scRNA-seq signatures of NK cells in bronchoalveolar lavage from COVID-19 patients. Unsupervised high-dimensional analysis of peripheral blood NK cells furthermore identified distinct NK cell immunotypes that were linked to disease severity. Hallmarks of these immunotypes were high expression of perforin, NKG2C, and Ksp37, reflecting increased presence of adaptive NK cells in circulation of patients with severe disease. Finally, arming of CD56(bright) NK cells was observed across COVID-19 disease states, driven by a defined protein-protein interaction network of inflammatory soluble factors. This study provides a detailed map of the NK cell activation landscape in COVID-19 disease. Twit Text FOAVip Natural killer cell immunotypes related to COVID-19 disease severity ????Sci Immunol http://www.kidney.de/pget.php?&tw=1&pmid=32826343 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=32826343 #FOAvip English Wikipedia <ref>{{Cite pmid|32826343}}</ref> Natural killer cell immunotypes related to COVID-19 disease severity #MMPMID32826343 Maucourant C; Filipovic I; Ponzetta A; Aleman S; Cornillet M; Hertwig L; Strunz B; Lentini A; Reinius B; Brownlie D; Cuapio A; Ask EH; Hull RM; Haroun-Izquierdo A; Schaffer M; Klingstrom J; Folkesson E; Buggert M; Sandberg JK; Eriksson LI; Rooyackers O; Ljunggren HG; Malmberg KJ; Michaelsson J; Marquardt N; Hammer Q; Stralin K; Bjorkstrom NK Sci Immunol 2020[Aug]; 5 (50): ä PMID32826343show ga Understanding innate immune responses in COVID-19 is important to decipher mechanisms of host responses and interpret disease pathogenesis. Natural killer (NK) cells are innate effector lymphocytes that respond to acute viral infections but might also contribute to immunopathology. Using 28-color flow cytometry, we here reveal strong NK cell activation across distinct subsets in peripheral blood of COVID-19 patients. This pattern was mirrored in scRNA-seq signatures of NK cells in bronchoalveolar lavage from COVID-19 patients. Unsupervised high-dimensional analysis of peripheral blood NK cells furthermore identified distinct NK cell immunotypes that were linked to disease severity. Hallmarks of these immunotypes were high expression of perforin, NKG2C, and Ksp37, reflecting increased presence of adaptive NK cells in circulation of patients with severe disease. Finally, arming of CD56(bright) NK cells was observed across COVID-19 disease states, driven by a defined protein-protein interaction network of inflammatory soluble factors. This study provides a detailed map of the NK cell activation landscape in COVID-19 disease. |*Severity of Illness Index[MESH] |Adaptive Immunity[MESH] |Betacoronavirus/*genetics/*immunology[MESH] |CD56 Antigen/metabolism[MESH] |COVID-19[MESH] |Coronavirus Infections/blood/*epidemiology/*immunology/pathology[MESH] |Female[MESH] |Flow Cytometry/methods[MESH] |Humans[MESH] |Killer Cells, Natural/*immunology[MESH] |Lymphocyte Activation[MESH] |Male[MESH] |Middle Aged[MESH] |Pandemics[MESH] |Phenotype[MESH] |Pneumonia, Viral/blood/*epidemiology/*immunology/pathology[MESH] |Polymerase Chain Reaction[MESH] |Prospective Studies[MESH] |Protein Interaction Maps/immunology[MESH] |Receptors, KIR/metabolism[MESH] |SARS-CoV-2[MESH] |Serologic Tests[MESH]Natural killer cell immunotypes related to COVID-19 disease severity (epmc).pdf DeepDyve Pubget Overpricing