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10.1073/pnas.2010146117 http://scihub22266oqcxt.onion/10.1073/pnas.2010146117 32826334!7486773!32826334     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Proc+Natl+Acad+Sci+U+S+A 2020 ; 117 (36): 22311-22322 Nephropedia Template TP {{tp|p=32826334|t=2020. Broad host range of SARS-CoV-2 predicted by comparative and structural analysis of ACE2 in vertebrates |pdf=|usr=}}{{32826334}} gab.com Text Broad host range of SARS-CoV-2 predicted by comparative and structural analysis of ACE2 in vertebrates JO: Proc Natl Acad Sci U S A http://www.kidney.de/pget.php?&tw=1&pmid=32826334 #FOAvip The novel coronavirus severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the cause of COVID-19. The main receptor of SARS-CoV-2, angiotensin I converting enzyme 2 (ACE2), is now undergoing extensive scrutiny to understand the routes of transmission and sensitivity in different species. Here, we utilized a unique dataset of ACE2 sequences from 410 vertebrate species, including 252 mammals, to study the conservation of ACE2 and its potential to be used as a receptor by SARS-CoV-2. We designed a five-category binding score based on the conservation properties of 25 amino acids important for the binding between ACE2 and the SARS-CoV-2 spike protein. Only mammals fell into the medium to very high categories and only catarrhine primates into the very high category, suggesting that they are at high risk for SARS-CoV-2 infection. We employed a protein structural analysis to qualitatively assess whether amino acid changes at variable residues would be likely to disrupt ACE2/SARS-CoV-2 spike protein binding and found the number of predicted unfavorable changes significantly correlated with the binding score. Extending this analysis to human population data, we found only rare (frequency <0.001) variants in 10/25 binding sites. In addition, we found significant signals of selection and accelerated evolution in the ACE2 coding sequence across all mammals, and specific to the bat lineage. Our results, if confirmed by additional experimental data, may lead to the identification of intermediate host species for SARS-CoV-2, guide the selection of animal models of COVID-19, and assist the conservation of animals both in native habitats and in human care. Twit Text FOAVip Broad host range of SARS-CoV-2 predicted by comparative and structural analysis of ACE2 in vertebrates ????Proc Natl Acad Sci U S A http://www.kidney.de/pget.php?&tw=1&pmid=32826334 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=32826334 #FOAvip English Wikipedia <ref>{{Cite pmid|32826334}}</ref> Broad host range of SARS-CoV-2 predicted by comparative and structural analysis of ACE2 in vertebrates #MMPMID32826334 Damas J; Hughes GM; Keough KC; Painter CA; Persky NS; Corbo M; Hiller M; Koepfli KP; Pfenning AR; Zhao H; Genereux DP; Swofford R; Pollard KS; Ryder OA; Nweeia MT; Lindblad-Toh K; Teeling EC; Karlsson EK; Lewin HA Proc Natl Acad Sci U S A 2020[Sep]; 117 (36): 22311-22322 PMID32826334show ga The novel coronavirus severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the cause of COVID-19. The main receptor of SARS-CoV-2, angiotensin I converting enzyme 2 (ACE2), is now undergoing extensive scrutiny to understand the routes of transmission and sensitivity in different species. Here, we utilized a unique dataset of ACE2 sequences from 410 vertebrate species, including 252 mammals, to study the conservation of ACE2 and its potential to be used as a receptor by SARS-CoV-2. We designed a five-category binding score based on the conservation properties of 25 amino acids important for the binding between ACE2 and the SARS-CoV-2 spike protein. Only mammals fell into the medium to very high categories and only catarrhine primates into the very high category, suggesting that they are at high risk for SARS-CoV-2 infection. We employed a protein structural analysis to qualitatively assess whether amino acid changes at variable residues would be likely to disrupt ACE2/SARS-CoV-2 spike protein binding and found the number of predicted unfavorable changes significantly correlated with the binding score. Extending this analysis to human population data, we found only rare (frequency <0.001) variants in 10/25 binding sites. In addition, we found significant signals of selection and accelerated evolution in the ACE2 coding sequence across all mammals, and specific to the bat lineage. Our results, if confirmed by additional experimental data, may lead to the identification of intermediate host species for SARS-CoV-2, guide the selection of animal models of COVID-19, and assist the conservation of animals both in native habitats and in human care. |Amino Acids[MESH] |Animals[MESH] |Betacoronavirus/metabolism/*physiology[MESH] |Binding Sites[MESH] |COVID-19[MESH] |Coronavirus Infections/*metabolism/virology[MESH] |Evolution, Molecular[MESH] |Genetic Variation[MESH] |Host Specificity[MESH] |Humans[MESH] |Pandemics[MESH] |Peptidyl-Dipeptidase A/*chemistry/*genetics/metabolism[MESH] |Pneumonia, Viral/*metabolism/virology[MESH] |Protein Binding[MESH] |Receptors, Virus/chemistry/genetics/metabolism[MESH] |SARS-CoV-2[MESH] |Selection, Genetic[MESH] |Spike Glycoprotein, Coronavirus/chemistry/metabolism[MESH]Broad host range of SARS-CoV-2 predicted by comparative and structural(epmc).pdf DeepDyve Pubget Overpricing