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10.3390/md18090435 http://scihub22266oqcxt.onion/10.3390/md18090435 32825645!7551811!32825645     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=32825645&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Mar+Drugs 2020 ; 18 (9): ä Nephropedia Template TP {{tp|p=32825645|t=2020. Carrageenans as Broad-Spectrum Microbicides: Current Status and Challenges |pdf=|usr=}}{{32825645}} gab.com Text Carrageenans as Broad-Spectrum Microbicides: Current Status and Challenges JO: Mar Drugs http://www.kidney.de/pget.php?&tw=1&pmid=32825645 #FOAvip Different kinds of red algae are enriched with chemically diverse carbohydrates. In particular, a group of sulfated polysaccharides, which were isolated from the cell walls of red algae, gained a large amount of attention due to their broad-spectrum antimicrobial activities. Within that group, carrageenans (CGs) were expected to be the first clinically applicable microbicides that could prevent various viral infections due to their superior antiviral potency and desirable safety profiles in subclinical studies. However, their anticipated beneficial effects could not be validated in human studies. To assess the value of a second attempt at pharmacologically developing CGs as a new class of preventive microbicides, all preclinical and clinical development processes of CG-based microbicides need to be thoroughly re-evaluated. In this review, the in vitro toxicities; in vivo safety profiles; and in vitro, ex vivo, and in vivo antiviral activities of CGs are summarized according to the study volume of their target viruses, which include human immunodeficiency virus, herpesviruses, respiratory viruses, human papillomavirus, dengue virus, and other viruses along with a description of their antiviral modes of action and development of antiviral resistance. This evaluation of the strengths and weaknesses of CGs will help provide future research directions that may lead to the successful development of CG-based antimicrobial prophylactics. Twit Text FOAVip Carrageenans as Broad-Spectrum Microbicides: Current Status and Challenges ????Mar Drugs http://www.kidney.de/pget.php?&tw=1&pmid=32825645 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=32825645 #FOAvip English Wikipedia <ref>{{Cite pmid|32825645}}</ref> Carrageenans as Broad-Spectrum Microbicides: Current Status and Challenges #MMPMID32825645 Lee C Mar Drugs 2020[Aug]; 18 (9): ä PMID32825645show ga Different kinds of red algae are enriched with chemically diverse carbohydrates. In particular, a group of sulfated polysaccharides, which were isolated from the cell walls of red algae, gained a large amount of attention due to their broad-spectrum antimicrobial activities. Within that group, carrageenans (CGs) were expected to be the first clinically applicable microbicides that could prevent various viral infections due to their superior antiviral potency and desirable safety profiles in subclinical studies. However, their anticipated beneficial effects could not be validated in human studies. To assess the value of a second attempt at pharmacologically developing CGs as a new class of preventive microbicides, all preclinical and clinical development processes of CG-based microbicides need to be thoroughly re-evaluated. In this review, the in vitro toxicities; in vivo safety profiles; and in vitro, ex vivo, and in vivo antiviral activities of CGs are summarized according to the study volume of their target viruses, which include human immunodeficiency virus, herpesviruses, respiratory viruses, human papillomavirus, dengue virus, and other viruses along with a description of their antiviral modes of action and development of antiviral resistance. This evaluation of the strengths and weaknesses of CGs will help provide future research directions that may lead to the successful development of CG-based antimicrobial prophylactics. |Animals[MESH] |Antiviral Agents/adverse effects/isolation & purification/*therapeutic use[MESH] |Carrageenan/adverse effects/isolation & purification/*therapeutic use[MESH] |Host-Pathogen Interactions[MESH] |Humans[MESH] |Rhodophyta/*chemistry[MESH]Carrageenans as Broad-Spectrum Microbicides: Current Status and Challe(epmc).pdf DeepDyve Pubget Overpricing