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10.3390/ijms21175953 http://scihub22266oqcxt.onion/10.3390/ijms21175953 32824985!7503668!32824985     free     free     free Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Int+J+Mol+Sci 2020 ; 21 (17): ä Nephropedia Template TP {{tp|p=32824985|t=2020. 4,4 -Diaminodiphenyl Sulfone (DDS) as an Inflammasome Competitor |pdf=|usr=}}{{32824985}} gab.com Text 4,4 -Diaminodiphenyl Sulfone (DDS) as an Inflammasome Competitor JO: Int J Mol Sci http://www.kidney.de/pget.php?&tw=1&pmid=32824985 #FOAvip The aim of this study is to examine the use of an inflammasome competitor as a preventative agent. Coronaviruses have zoonotic potential due to the adaptability of their S protein to bind receptors of other species, most notably demonstrated by SARS-CoV. The binding of SARS-CoV-2 to TLR (Toll-like receptor) causes the release of pro-IL-1beta, which is cleaved by caspase-1, followed by the formation and activation of the inflammasome, which is a mediator of lung inflammation, fever, and fibrosis. The NLRP3 (NACHT, LRR and PYD domains-containing protein 3) inflammasome is implicated in a variety of human diseases including Alzheimer's disease (AD), prion diseases, type 2 diabetes, and numerous infectious diseases. By examining the use of 4,4'-diaminodiphenyl sulfone (DDS) in the treatment of patients with Hansen's disease, also diagnosed as Alzheimer's disease, this study demonstrates the diverse mechanisms involved in the activation of inflammasomes. TLRs, due to genetic polymorphisms, can alter the immune response to a wide variety of microbial ligands, including viruses. In particular, TLR2Arg(677)Trp was reported to be exclusively present in Korean patients with lepromatous leprosy (LL). Previously, mutation of the intracellular domain of TLR2 has demonstrated its role in determining the susceptibility to LL, though LL was successfully treated using a combination of DDS with rifampicin and clofazimine. Of the three tested antibiotics, DDS was effective in the molecular regulation of NLRP3 inflammasome activators that are important in mild cognitive impairment (MCI), Parkinson's disease (PD), and AD. The specific targeting of NLRP3 itself or up-/downstream factors of the NLRP3 inflammasome by DDS may be responsible for its observed preventive effects, functioning as a competitor. Twit Text FOAVip 4,4 -Diaminodiphenyl Sulfone (DDS) as an Inflammasome Competitor ????Int J Mol Sci http://www.kidney.de/pget.php?&tw=1&pmid=32824985 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=32824985 #FOAvip English Wikipedia <ref>{{Cite pmid|32824985}}</ref> 4,4 -Diaminodiphenyl Sulfone (DDS) as an Inflammasome Competitor #MMPMID32824985 Lee JH; An HK; Sohn MG; Kivela P; Oh S Int J Mol Sci 2020[Aug]; 21 (17): ä PMID32824985show ga The aim of this study is to examine the use of an inflammasome competitor as a preventative agent. Coronaviruses have zoonotic potential due to the adaptability of their S protein to bind receptors of other species, most notably demonstrated by SARS-CoV. The binding of SARS-CoV-2 to TLR (Toll-like receptor) causes the release of pro-IL-1beta, which is cleaved by caspase-1, followed by the formation and activation of the inflammasome, which is a mediator of lung inflammation, fever, and fibrosis. The NLRP3 (NACHT, LRR and PYD domains-containing protein 3) inflammasome is implicated in a variety of human diseases including Alzheimer's disease (AD), prion diseases, type 2 diabetes, and numerous infectious diseases. By examining the use of 4,4'-diaminodiphenyl sulfone (DDS) in the treatment of patients with Hansen's disease, also diagnosed as Alzheimer's disease, this study demonstrates the diverse mechanisms involved in the activation of inflammasomes. TLRs, due to genetic polymorphisms, can alter the immune response to a wide variety of microbial ligands, including viruses. In particular, TLR2Arg(677)Trp was reported to be exclusively present in Korean patients with lepromatous leprosy (LL). Previously, mutation of the intracellular domain of TLR2 has demonstrated its role in determining the susceptibility to LL, though LL was successfully treated using a combination of DDS with rifampicin and clofazimine. Of the three tested antibiotics, DDS was effective in the molecular regulation of NLRP3 inflammasome activators that are important in mild cognitive impairment (MCI), Parkinson's disease (PD), and AD. The specific targeting of NLRP3 itself or up-/downstream factors of the NLRP3 inflammasome by DDS may be responsible for its observed preventive effects, functioning as a competitor. |Alzheimer Disease/pathology[MESH] |COVID-19[MESH] |Clofazimine/pharmacology[MESH] |Cognitive Dysfunction/pathology[MESH] |Coronavirus Infections/*drug therapy[MESH] |Dapsone/*pharmacology[MESH] |Humans[MESH] |Inflammasomes/*metabolism[MESH] |Interleukin-1beta/metabolism[MESH] |Leprosy/drug therapy/genetics[MESH] |NLR Family, Pyrin Domain-Containing 3 Protein/*metabolism[MESH] |Pandemics[MESH] |Parkinsonian Disorders/pathology[MESH] |Pneumonia, Viral/*drug therapy[MESH] |Rifampin/pharmacology[MESH] |Spike Glycoprotein, Coronavirus/metabolism[MESH]4,4 -Diaminodiphenyl Sulfone (DDS) as an Inflammasome Competitor (epmc).pdf DeepDyve Pubget Overpricing