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10.3390/ijms21165932 http://scihub22266oqcxt.onion/10.3390/ijms21165932 32824753!7460647!32824753     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Int+J+Mol+Sci 2020 ; 21 (16): ä Nephropedia Template TP {{tp|p=32824753|t=2020. Deciphering SARS-CoV-2 Virologic and Immunologic Features |pdf=|usr=}}{{32824753}} gab.com Text Deciphering SARS-CoV-2 Virologic and Immunologic Features JO: Int J Mol Sci http://www.kidney.de/pget.php?&tw=1&pmid=32824753 #FOAvip Severe acute respiratory syndrome coronavirus (SARS-CoV)-2 and its associated pathology, COVID-19, have been of particular concerns these last months due to the worldwide burden they represent. The number of cases requiring intensive care being the critical point in this epidemic, a better understanding of the pathophysiology leading to these severe cases is urgently needed. Tissue lesions can be caused by the pathogen or can be driven by an overwhelmed immune response. Focusing on SARS-CoV-2, we and others have observed that this virus can trigger indeed an immune response that can be dysregulated in severe patients and leading to further injury to multiple organs. The purpose of the review is to bring to light the current knowledge about SARS-CoV-2 virologic and immunologic features. Thus, we address virus biology, life cycle, tropism for many organs and how ultimately it will affect several host biological and physiological functions, notably the immune response. Given that therapeutic avenues are now highly warranted, we also discuss the immunotherapies available to manage the infection and the clinical outcomes. Twit Text FOAVip Deciphering SARS-CoV-2 Virologic and Immunologic Features ????Int J Mol Sci http://www.kidney.de/pget.php?&tw=1&pmid=32824753 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=32824753 #FOAvip English Wikipedia <ref>{{Cite pmid|32824753}}</ref> Deciphering SARS-CoV-2 Virologic and Immunologic Features #MMPMID32824753 Lebeau G; Vagner D; Frumence E; Ah-Pine F; Guillot X; Nobecourt E; Raffray L; Gasque P Int J Mol Sci 2020[Aug]; 21 (16): ä PMID32824753show ga Severe acute respiratory syndrome coronavirus (SARS-CoV)-2 and its associated pathology, COVID-19, have been of particular concerns these last months due to the worldwide burden they represent. The number of cases requiring intensive care being the critical point in this epidemic, a better understanding of the pathophysiology leading to these severe cases is urgently needed. Tissue lesions can be caused by the pathogen or can be driven by an overwhelmed immune response. Focusing on SARS-CoV-2, we and others have observed that this virus can trigger indeed an immune response that can be dysregulated in severe patients and leading to further injury to multiple organs. The purpose of the review is to bring to light the current knowledge about SARS-CoV-2 virologic and immunologic features. Thus, we address virus biology, life cycle, tropism for many organs and how ultimately it will affect several host biological and physiological functions, notably the immune response. Given that therapeutic avenues are now highly warranted, we also discuss the immunotherapies available to manage the infection and the clinical outcomes. |*Coronavirus Infections/immunology/pathology/therapy[MESH] |*Pandemics[MESH] |*Pneumonia, Viral/immunology/pathology/therapy[MESH] |Age Factors[MESH] |Angiotensin-Converting Enzyme 2[MESH] |Betacoronavirus/*immunology[MESH] |COVID-19[MESH] |Coronavirus RNA-Dependent RNA Polymerase[MESH] |Cytokines/blood[MESH] |Humans[MESH] |Immunotherapy/methods[MESH] |Lung/pathology[MESH] |Peptidyl-Dipeptidase A/metabolism[MESH] |RNA-Dependent RNA Polymerase/metabolism[MESH] |SARS-CoV-2[MESH] |Viral Nonstructural Proteins/metabolism[MESH] |Viral Tropism/physiology[MESH] |Virus Assembly/physiology[MESH]Deciphering SARS-CoV-2 Virologic and Immunologic Features (epmc).pdf DeepDyve Pubget Overpricing