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10.3390/ijms21165856 http://scihub22266oqcxt.onion/10.3390/ijms21165856 32824072!7461590!32824072     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Int+J+Mol+Sci 2020 ; 21 (16): ä Nephropedia Template TP {{tp|p=32824072|t=2020. New Anti SARS-Cov-2 Targets for Quinoline Derivatives Chloroquine and Hydroxychloroquine |pdf=|usr=}}{{32824072}} gab.com Text New Anti SARS-Cov-2 Targets for Quinoline Derivatives Chloroquine and Hydroxychloroquine JO: Int J Mol Sci http://www.kidney.de/pget.php?&tw=1&pmid=32824072 #FOAvip The rapid spread of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has created a severe global health crisis. In this paper, we used docking and simulation methods to identify potential targets and the mechanism of action of chloroquine (CQ) and hydroxychloroquine (HCQ) against SARS-CoV-2. Our results showed that both CQ and HCQ influenced the functionality of the envelope (E) protein, necessary in the maturation processes of the virus, due to interactions that modify the flexibility of the protein structure. Furthermore, CQ and HCQ also influenced the proofreading and capping of viral RNA in SARS-CoV-2, performed by nsp10/nsp14 and nsp10/nsp16. In particular, HCQ demonstrated a better energy binding with the examined targets compared to CQ, probably due to the hydrogen bonding of the hydroxyl group of HCQ with polar amino acid residues. Twit Text FOAVip New Anti SARS-Cov-2 Targets for Quinoline Derivatives Chloroquine and Hydroxychloroquine ????Int J Mol Sci http://www.kidney.de/pget.php?&tw=1&pmid=32824072 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=32824072 #FOAvip English Wikipedia <ref>{{Cite pmid|32824072}}</ref> New Anti SARS-Cov-2 Targets for Quinoline Derivatives Chloroquine and Hydroxychloroquine #MMPMID32824072 Gentile D; Fuochi V; Rescifina A; Furneri PM Int J Mol Sci 2020[Aug]; 21 (16): ä PMID32824072show ga The rapid spread of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has created a severe global health crisis. In this paper, we used docking and simulation methods to identify potential targets and the mechanism of action of chloroquine (CQ) and hydroxychloroquine (HCQ) against SARS-CoV-2. Our results showed that both CQ and HCQ influenced the functionality of the envelope (E) protein, necessary in the maturation processes of the virus, due to interactions that modify the flexibility of the protein structure. Furthermore, CQ and HCQ also influenced the proofreading and capping of viral RNA in SARS-CoV-2, performed by nsp10/nsp14 and nsp10/nsp16. In particular, HCQ demonstrated a better energy binding with the examined targets compared to CQ, probably due to the hydrogen bonding of the hydroxyl group of HCQ with polar amino acid residues. |Antiviral Agents/*pharmacology[MESH] |Betacoronavirus/*drug effects[MESH] |COVID-19[MESH] |COVID-19 Drug Treatment[MESH] |Chloroquine/*pharmacology[MESH] |Coronavirus Envelope Proteins[MESH] |Coronavirus Infections/drug therapy[MESH] |Exoribonucleases/*metabolism[MESH] |Humans[MESH] |Hydroxychloroquine/*pharmacology[MESH] |Methyltransferases/*metabolism[MESH] |Molecular Docking Simulation[MESH] |Pandemics[MESH] |Pneumonia, Viral/drug therapy[MESH] |RNA, Viral/drug effects/genetics[MESH] |SARS-CoV-2[MESH] |Viral Envelope Proteins/drug effects/metabolism[MESH] |Viral Nonstructural Proteins/*metabolism[MESH]New Anti SARS-Cov-2 Targets for Quinoline Derivatives Chloroquine and (epmc).pdf DeepDyve Pubget Overpricing