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10.1016/j.coi.2020.07.005 http://scihub22266oqcxt.onion/10.1016/j.coi.2020.07.005 32823144!7431399!32823144     free     free     free       Curr+Opin+Immunol 2020 ; 66 (ä): 98-107 Nephropedia Template TP {{tp|p=32823144|t=2020. The host targeting effect of chloroquine in malaria |pdf=|usr=}}{{32823144}} gab.com Text The host targeting effect of chloroquine in malaria JO: Curr Opin Immunol http://www.kidney.de/pget.php?&tw=1&pmid=32823144 #FOAvip Due to the rapid onset and spread of the COVID-19 pandemic, the treatment of COVID-19 patients by hydroxychloroquine alone or in combination with other drugs has captured a great deal of attention and triggered considerable debate. Historically, the worldwide use of quinoline based-drugs has led to a spectacular reduction in death from malaria. Unfortunately, scientists have been forced to seek alternative drugs to treat malaria due to the emergence of chloroquine-resistant parasites in the 1960s. The repurposing of hydroxychloroquine against viral infections, various types of cancer and autoimmune diseases has been ongoing for more than 70 years, with no clear understanding of its mechanism of action (MOA). Here, we closely examine the MOA of this old but influential drug in and beyond malaria. Better insights into how chloroquine targets the host's cellular and immune responses may help to develop applications against to new pathogens and diseases, and perhaps even restore the clinical utility of chloroquine against malaria. Twit Text FOAVip The host targeting effect of chloroquine in malaria ????Curr Opin Immunol http://www.kidney.de/pget.php?&tw=1&pmid=32823144 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=32823144 #FOAvip English Wikipedia <ref>{{Cite pmid|32823144}}</ref> The host targeting effect of chloroquine in malaria #MMPMID32823144 Coban C Curr Opin Immunol 2020[Oct]; 66 (ä): 98-107 PMID32823144show ga Due to the rapid onset and spread of the COVID-19 pandemic, the treatment of COVID-19 patients by hydroxychloroquine alone or in combination with other drugs has captured a great deal of attention and triggered considerable debate. Historically, the worldwide use of quinoline based-drugs has led to a spectacular reduction in death from malaria. Unfortunately, scientists have been forced to seek alternative drugs to treat malaria due to the emergence of chloroquine-resistant parasites in the 1960s. The repurposing of hydroxychloroquine against viral infections, various types of cancer and autoimmune diseases has been ongoing for more than 70 years, with no clear understanding of its mechanism of action (MOA). Here, we closely examine the MOA of this old but influential drug in and beyond malaria. Better insights into how chloroquine targets the host's cellular and immune responses may help to develop applications against to new pathogens and diseases, and perhaps even restore the clinical utility of chloroquine against malaria. |Animals[MESH] |COVID-19 Drug Treatment[MESH] |Chloroquine/*pharmacology/*therapeutic use[MESH] |Humans[MESH] |Hydroxychloroquine/pharmacology/therapeutic use[MESH] |Malaria/*drug therapy[MESH] |Pandemics/prevention & control[MESH]The host targeting effect of chloroquine in malaria (epmc).pdf DeepDyve Pubget Overpricing