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10.1016/S0140-6736(20)31757-8 http://scihub22266oqcxt.onion/10.1016/S0140-6736(20)31757-8 32822564!7434477!32822564     free     free     free Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 263.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 263.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 263.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 263.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 263.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Lancet 2020 ; 396 (10251): 603-611 Nephropedia Template TP {{tp|p=32822564|t=2020. Effects of a major deletion in the SARS-CoV-2 genome on the severity of infection and the inflammatory response: an observational cohort study |pdf=|usr=}}{{32822564}} gab.com Text Effects of a major deletion in the SARS-CoV-2 genome on the severity of infection and the inflammatory response: an observational cohort study JO: Lancet http://www.kidney.de/pget.php?&tw=1&pmid=32822564 #FOAvip BACKGROUND: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants with a 382-nucleotide deletion (?382) in the open reading frame 8 (ORF8) region of the genome have been detected in Singapore and other countries. We investigated the effect of this deletion on the clinical features of infection. METHODS: We retrospectively identified patients who had been screened for the ?382 variant and recruited to the PROTECT study-a prospective observational cohort study conducted at seven public hospitals in Singapore. We collected clinical, laboratory, and radiological data from patients' electronic medical records and serial blood and respiratory samples taken during hospitalisation and after discharge. Individuals infected with the ?382 variant were compared with those infected with wild-type SARS-CoV-2. Exact logistic regression was used to examine the association between the infection groups and the development of hypoxia requiring supplemental oxygen (an indicator of severe COVID-19, the primary endpoint). Follow-up for the study's primary endpoint is completed. FINDINGS: Between Jan 22 and March 21, 2020, 278 patients with PCR-confirmed SARS-CoV-2 infection were screened for the ?382 deletion and 131 were enrolled onto the study, of whom 92 (70%) were infected with the wild-type virus, ten (8%) had a mix of wild-type and ?382-variant viruses, and 29 (22%) had only the ?382 variant. Development of hypoxia requiring supplemental oxygen was less frequent in the ?382 variant group (0 [0%] of 29 patients) than in the wild-type only group (26 [28%] of 92; absolute difference 28% [95% CI 14-28]). After adjusting for age and presence of comorbidities, infection with the ?382 variant only was associated with lower odds of developing hypoxia requiring supplemental oxygen (adjusted odds ratio 0.07 [95% CI 0.00-0.48]) compared with infection with wild-type virus only. INTERPRETATION: The ?382 variant of SARS-CoV-2 seems to be associated with a milder infection. The observed clinical effects of deletions in ORF8 could have implications for the development of treatments and vaccines. FUNDING: National Medical Research Council Singapore. Twit Text FOAVip Effects of a major deletion in the SARS-CoV-2 genome on the severity of infection and the inflammatory response: an observational cohort study ????Lancet http://www.kidney.de/pget.php?&tw=1&pmid=32822564 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=32822564 #FOAvip English Wikipedia <ref>{{Cite pmid|32822564}}</ref> Effects of a major deletion in the SARS-CoV-2 genome on the severity of infection and the inflammatory response: an observational cohort study #MMPMID32822564 Young BE; Fong SW; Chan YH; Mak TM; Ang LW; Anderson DE; Lee CY; Amrun SN; Lee B; Goh YS; Su YCF; Wei WE; Kalimuddin S; Chai LYA; Pada S; Tan SY; Sun L; Parthasarathy P; Chen YYC; Barkham T; Lin RTP; Maurer-Stroh S; Leo YS; Wang LF; Renia L; Lee VJ; Smith GJD; Lye DC; Ng LFP Lancet 2020[Aug]; 396 (10251): 603-611 PMID32822564show ga BACKGROUND: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants with a 382-nucleotide deletion (?382) in the open reading frame 8 (ORF8) region of the genome have been detected in Singapore and other countries. We investigated the effect of this deletion on the clinical features of infection. METHODS: We retrospectively identified patients who had been screened for the ?382 variant and recruited to the PROTECT study-a prospective observational cohort study conducted at seven public hospitals in Singapore. We collected clinical, laboratory, and radiological data from patients' electronic medical records and serial blood and respiratory samples taken during hospitalisation and after discharge. Individuals infected with the ?382 variant were compared with those infected with wild-type SARS-CoV-2. Exact logistic regression was used to examine the association between the infection groups and the development of hypoxia requiring supplemental oxygen (an indicator of severe COVID-19, the primary endpoint). Follow-up for the study's primary endpoint is completed. FINDINGS: Between Jan 22 and March 21, 2020, 278 patients with PCR-confirmed SARS-CoV-2 infection were screened for the ?382 deletion and 131 were enrolled onto the study, of whom 92 (70%) were infected with the wild-type virus, ten (8%) had a mix of wild-type and ?382-variant viruses, and 29 (22%) had only the ?382 variant. Development of hypoxia requiring supplemental oxygen was less frequent in the ?382 variant group (0 [0%] of 29 patients) than in the wild-type only group (26 [28%] of 92; absolute difference 28% [95% CI 14-28]). After adjusting for age and presence of comorbidities, infection with the ?382 variant only was associated with lower odds of developing hypoxia requiring supplemental oxygen (adjusted odds ratio 0.07 [95% CI 0.00-0.48]) compared with infection with wild-type virus only. INTERPRETATION: The ?382 variant of SARS-CoV-2 seems to be associated with a milder infection. The observed clinical effects of deletions in ORF8 could have implications for the development of treatments and vaccines. FUNDING: National Medical Research Council Singapore. |*Gene Deletion[MESH] |Adult[MESH] |Aged[MESH] |Betacoronavirus[MESH] |COVID-19[MESH] |Coronavirus Infections/complications/epidemiology/*virology[MESH] |Genome, Viral/*genetics[MESH] |Humans[MESH] |Hypoxia/etiology/therapy[MESH] |Middle Aged[MESH] |Open Reading Frames[MESH] |Pandemics[MESH] |Pneumonia, Viral/complications/epidemiology/*virology[MESH] |Prospective Studies[MESH] |Respiratory Therapy[MESH] |SARS-CoV-2[MESH] |Severity of Illness Index[MESH] |Singapore/epidemiology[MESH]Effects of a major deletion in the SARS-CoV-2 genome on the severity o(epmc).pdf DeepDyve Pubget Overpricing