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10.1084/jem.20191220 http://scihub22266oqcxt.onion/10.1084/jem.20191220 32820330!7953731!32820330     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       J+Exp+Med 2020 ; 217 (12): ä Nephropedia Template TP {{tp|p=32820330|t=2020. Early type I IFN blockade improves the efficacy of viral vaccines |pdf=|usr=}}{{32820330}} gab.com Text Early type I IFN blockade improves the efficacy of viral vaccines JO: J Exp Med http://www.kidney.de/pget.php?&tw=1&pmid=32820330 #FOAvip Type I interferons (IFN-I) are a major antiviral defense and are critical for the activation of the adaptive immune system. However, early viral clearance by IFN-I could limit antigen availability, which could in turn impinge upon the priming of the adaptive immune system. In this study, we hypothesized that transient IFN-I blockade could increase antigen presentation after acute viral infection. To test this hypothesis, we infected mice with viruses coadministered with a single dose of IFN-I receptor-blocking antibody to induce a short-term blockade of the IFN-I pathway. This resulted in a transient "spike" in antigen levels, followed by rapid antigen clearance. Interestingly, short-term IFN-I blockade after coronavirus, flavivirus, rhabdovirus, or arenavirus infection induced a long-lasting enhancement of immunological memory that conferred improved protection upon subsequent reinfections. Short-term IFN-I blockade also improved the efficacy of viral vaccines. These findings demonstrate a novel mechanism by which IFN-I regulate immunological memory and provide insights for rational vaccine design. Twit Text FOAVip Early type I IFN blockade improves the efficacy of viral vaccines ????J Exp Med http://www.kidney.de/pget.php?&tw=1&pmid=32820330 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=32820330 #FOAvip English Wikipedia <ref>{{Cite pmid|32820330}}</ref> Early type I IFN blockade improves the efficacy of viral vaccines #MMPMID32820330 Palacio N; Dangi T; Chung YR; Wang Y; Loredo-Varela JL; Zhang Z; Penaloza-MacMaster P J Exp Med 2020[Dec]; 217 (12): ä PMID32820330show ga Type I interferons (IFN-I) are a major antiviral defense and are critical for the activation of the adaptive immune system. However, early viral clearance by IFN-I could limit antigen availability, which could in turn impinge upon the priming of the adaptive immune system. In this study, we hypothesized that transient IFN-I blockade could increase antigen presentation after acute viral infection. To test this hypothesis, we infected mice with viruses coadministered with a single dose of IFN-I receptor-blocking antibody to induce a short-term blockade of the IFN-I pathway. This resulted in a transient "spike" in antigen levels, followed by rapid antigen clearance. Interestingly, short-term IFN-I blockade after coronavirus, flavivirus, rhabdovirus, or arenavirus infection induced a long-lasting enhancement of immunological memory that conferred improved protection upon subsequent reinfections. Short-term IFN-I blockade also improved the efficacy of viral vaccines. These findings demonstrate a novel mechanism by which IFN-I regulate immunological memory and provide insights for rational vaccine design. |Animals[MESH] |Antibodies, Blocking/immunology/pharmacology[MESH] |Antibodies, Viral/immunology[MESH] |Antigen Presentation/immunology[MESH] |CD8-Positive T-Lymphocytes/metabolism[MESH] |Dendritic Cells/immunology[MESH] |Disease Models, Animal[MESH] |Gene Expression/immunology[MESH] |HEK293 Cells[MESH] |Humans[MESH] |Immunogenicity, Vaccine/*immunology[MESH] |Immunologic Memory[MESH] |Interferon Type I/*antagonists & inhibitors[MESH] |Interferon-alpha/genetics/*immunology[MESH] |Mice[MESH] |Mice, Inbred BALB C[MESH] |Mice, Inbred C57BL[MESH] |Mice, Knockout[MESH] |Receptor, Interferon alpha-beta/genetics/*immunology[MESH] |Transfection[MESH] |Viral Vaccines/*immunology[MESH] |Zika Virus Infection/*immunology/virology[MESH]Early type I IFN blockade improves the efficacy of viral vaccines (epmc).pdf DeepDyve Pubget Overpricing