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10.1038/s41598-020-70827-z http://scihub22266oqcxt.onion/10.1038/s41598-020-70827-z 32820179!7441380!32820179     free     free     free Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 269.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Sci+Rep 2020 ; 10 (1): 14031 Nephropedia Template TP {{tp|p=32820179|t=2020. Evolutionary and structural analyses of SARS-CoV-2 D614G spike protein mutation now documented worldwide |pdf=|usr=}}{{32820179}} gab.com Text Evolutionary and structural analyses of SARS-CoV-2 D614G spike protein mutation now documented worldwide JO: Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=32820179 #FOAvip The COVID-19 pandemic, caused by the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), was declared on March 11, 2020 by the World Health Organization. As of the 31st of May, 2020, there have been more than 6 million COVID-19 cases diagnosed worldwide and over 370,000 deaths, according to Johns Hopkins. Thousands of SARS-CoV-2 strains have been sequenced to date, providing a valuable opportunity to investigate the evolution of the virus on a global scale. We performed a phylogenetic analysis of over 1,225 SARS-CoV-2 genomes spanning from late December 2019 to mid-March 2020. We identified a missense mutation, D614G, in the spike protein of SARS-CoV-2, which has emerged as a predominant clade in Europe (954 of 1,449 (66%) sequences) and is spreading worldwide (1,237 of 2,795 (44%) sequences). Molecular dating analysis estimated the emergence of this clade around mid-to-late January (10-25 January) 2020. We also applied structural bioinformatics to assess the potential impact of D614G on the virulence and epidemiology of SARS-CoV-2. In silico analyses on the spike protein structure suggests that the mutation is most likely neutral to protein function as it relates to its interaction with the human ACE2 receptor. The lack of clinical metadata available prevented our investigation of association between viral clade and disease severity phenotype. Future work that can leverage clinical outcome data with both viral and human genomic diversity is needed to monitor the pandemic. Twit Text FOAVip Evolutionary and structural analyses of SARS-CoV-2 D614G spike protein mutation now documented worldwide ????Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=32820179 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=32820179 #FOAvip English Wikipedia <ref>{{Cite pmid|32820179}}</ref> Evolutionary and structural analyses of SARS-CoV-2 D614G spike protein mutation now documented worldwide #MMPMID32820179 Isabel S; Grana-Miraglia L; Gutierrez JM; Bundalovic-Torma C; Groves HE; Isabel MR; Eshaghi A; Patel SN; Gubbay JB; Poutanen T; Guttman DS; Poutanen SM Sci Rep 2020[Aug]; 10 (1): 14031 PMID32820179show ga The COVID-19 pandemic, caused by the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), was declared on March 11, 2020 by the World Health Organization. As of the 31st of May, 2020, there have been more than 6 million COVID-19 cases diagnosed worldwide and over 370,000 deaths, according to Johns Hopkins. Thousands of SARS-CoV-2 strains have been sequenced to date, providing a valuable opportunity to investigate the evolution of the virus on a global scale. We performed a phylogenetic analysis of over 1,225 SARS-CoV-2 genomes spanning from late December 2019 to mid-March 2020. We identified a missense mutation, D614G, in the spike protein of SARS-CoV-2, which has emerged as a predominant clade in Europe (954 of 1,449 (66%) sequences) and is spreading worldwide (1,237 of 2,795 (44%) sequences). Molecular dating analysis estimated the emergence of this clade around mid-to-late January (10-25 January) 2020. We also applied structural bioinformatics to assess the potential impact of D614G on the virulence and epidemiology of SARS-CoV-2. In silico analyses on the spike protein structure suggests that the mutation is most likely neutral to protein function as it relates to its interaction with the human ACE2 receptor. The lack of clinical metadata available prevented our investigation of association between viral clade and disease severity phenotype. Future work that can leverage clinical outcome data with both viral and human genomic diversity is needed to monitor the pandemic. |*Evolution, Molecular[MESH] |Adolescent[MESH] |Adult[MESH] |Aged[MESH] |Aged, 80 and over[MESH] |Angiotensin-Converting Enzyme 2[MESH] |Base Sequence[MESH] |Betacoronavirus/*chemistry/pathogenicity[MESH] |COVID-19[MESH] |Child[MESH] |Child, Preschool[MESH] |Computer Simulation[MESH] |Coronavirus Infections/*epidemiology/virology[MESH] |Female[MESH] |Genome, Viral/genetics[MESH] |Humans[MESH] |Infant[MESH] |Male[MESH] |Middle Aged[MESH] |Mutation, Missense[MESH] |Pandemics[MESH] |Peptidyl-Dipeptidase A/metabolism[MESH] |Phylogeny[MESH] |Pneumonia, Viral/*epidemiology/virology[MESH] |Protein Conformation[MESH] |SARS-CoV-2[MESH] |Spike Glycoprotein, Coronavirus/*chemistry/*genetics/metabolism[MESH] |Virulence/genetics[MESH]Evolutionary and structural analyses of SARS-CoV-2 D614G spike protein(epmc).pdf DeepDyve Pubget Overpricing