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10.1016/j.bpc.2020.106452

http://scihub22266oqcxt.onion/10.1016/j.bpc.2020.106452
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suck abstract from ncbi


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pmid32818817      Biophys+Chem 2020 ; 266 (ä): 106452
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  • Host-membrane interacting interface of the SARS coronavirus envelope protein: Immense functional potential of C-terminal domain #MMPMID32818817
  • Mukherjee S; Bhattacharyya D; Bhunia A
  • Biophys Chem 2020[Nov]; 266 (ä): 106452 PMID32818817show ga
  • The Envelope (E) protein in SARS Coronavirus (CoV) is a small structural protein, incorporated as part of the envelope. A major fraction of the protein has been known to be associated with the host membranes, particularly organelles related to intracellular trafficking, prompting CoV packaging and propagation. Studies have elucidated the central hydrophobic transmembrane domain of the E protein being responsible for much of the viroporin activity in favor of the virus. However, newer insights into the organizational principles at the membranous compartments within the host cells suggest further complexity of the system. The lesser hydrophobic Carboxylic-terminal of the protein harbors interesting amino acid sequences- suggesting at the prevalence of membrane-directed amyloidogenic properties that remains mostly elusive. These highly conserved segments indicate at several potential membrane-associated functional roles that can redefine our comprehensive understanding of the protein. This should prompt further studies in designing and characterizing of effective targeted therapeutic measures.
  • |Amino Acid Sequence[MESH]
  • |Animals[MESH]
  • |Betacoronavirus/chemistry/*physiology[MESH]
  • |COVID-19[MESH]
  • |Cell Membrane/*metabolism/pathology/virology[MESH]
  • |Coronavirus Envelope Proteins[MESH]
  • |Coronavirus Infections/*metabolism/pathology/virology[MESH]
  • |Host-Pathogen Interactions[MESH]
  • |Humans[MESH]
  • |Models, Molecular[MESH]
  • |Pandemics[MESH]
  • |Pneumonia, Viral/*metabolism/pathology/virology[MESH]
  • |Protein Domains[MESH]
  • |SARS-CoV-2[MESH]
  • |Sequence Alignment[MESH]


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