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10.1016/S1473-3099(20)30651-4

http://scihub22266oqcxt.onion/10.1016/S1473-3099(20)30651-4
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32818434!7431129!32818434
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suck abstract from ncbi


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pmid32818434      Lancet+Infect+Dis 2020 ; 20 (11): e276-e288
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  • COVID-19 and multisystem inflammatory syndrome in children and adolescents #MMPMID32818434
  • Jiang L; Tang K; Levin M; Irfan O; Morris SK; Wilson K; Klein JD; Bhutta ZA
  • Lancet Infect Dis 2020[Nov]; 20 (11): e276-e288 PMID32818434show ga
  • As severe acute respiratory syndrome coronavirus 2 continues to spread worldwide, there have been increasing reports from Europe, North America, Asia, and Latin America describing children and adolescents with COVID-19-associated multisystem inflammatory conditions. However, the association between multisystem inflammatory syndrome in children and COVID-19 is still unknown. We review the epidemiology, causes, clinical features, and current treatment protocols for multisystem inflammatory syndrome in children and adolescents associated with COVID-19. We also discuss the possible underlying pathophysiological mechanisms for COVID-19-induced inflammatory processes, which can lead to organ damage in paediatric patients who are severely ill. These insights provide evidence for the need to develop a clear case definition and treatment protocol for this new condition and also shed light on future therapeutic interventions and the potential for vaccine development. TRANSLATIONS: For the French, Chinese, Arabic, Spanish and Russian translations of the abstract see Supplementary Materials section.
  • |*Betacoronavirus[MESH]
  • |Adolescent[MESH]
  • |Anti-Inflammatory Agents, Non-Steroidal/therapeutic use[MESH]
  • |Antiviral Agents/therapeutic use[MESH]
  • |COVID-19[MESH]
  • |COVID-19 Drug Treatment[MESH]
  • |Child[MESH]
  • |Child, Preschool[MESH]
  • |Coronavirus Infections/drug therapy/*epidemiology/*immunology/virology[MESH]
  • |Female[MESH]
  • |Humans[MESH]
  • |Immunoglobulins, Intravenous/therapeutic use[MESH]
  • |Infant[MESH]
  • |Infant, Newborn[MESH]
  • |Male[MESH]
  • |Mucocutaneous Lymph Node Syndrome/drug therapy/immunology[MESH]
  • |Pandemics[MESH]
  • |Pneumonia, Viral/drug therapy/*epidemiology/*immunology/virology[MESH]
  • |Risk Factors[MESH]
  • |SARS-CoV-2[MESH]
  • |Systemic Inflammatory Response Syndrome/drug therapy/*epidemiology/*immunology/virology[MESH]


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