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10.21203/rs.3.rs-56210/v1 http://scihub22266oqcxt.onion/10.21203/rs.3.rs-56210/v1 32818209!7430584!32818209     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Res+Sq 2020 ; ä (ä): ä Nephropedia Template TP {{tp|p=32818209|t=2020. Association Between Antecedent Statin Use and Decreased Mortality in Hospitalized Patients with COVID-19 |pdf=|usr=}}{{32818209}} gab.com Text Association Between Antecedent Statin Use and Decreased Mortality in Hospitalized Patients with COVID-19 JO: Res Sq http://www.kidney.de/pget.php?&tw=1&pmid=32818209 #FOAvip The coronavirus disease 2019 (COVID-19), caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), can result in a hyperinflammatory state, leading to acute respiratory distress syndrome (ARDS), myocardial injury, and thrombotic complications, among other sequelae. Statins, which are known to have anti-inflammatory and antithrombotic properties, have been studied in the setting of other viral infections and ARDS, but their benefit has not been assessed in COVID-19. Thus, we sought to determine whether antecedent statin use is associated with lower in-hospital mortality in patients hospitalized for COVID-19. This is a retrospective analysis of patients admitted with COVID-19 from February 1 (st) through May 12 (th) , 2020 with study period ending on June 11 (th) , 2020. Antecedent statin use was assessed using medication information available in the electronic medical record. We constructed a multivariable logistic regression model to predict the propensity of receiving statins, adjusting for baseline socio-demographic and clinical characteristics, and outpatient medications. The primary endpoint included in-hospital mortality within 30 days. A total of 2626 patients were admitted during the study period, of whom 951 (36.2%) were antecedent statin users. Among 1296 patients (648 statin users, 648 non-statin users) identified with 1:1 propensity-score matching, demographic, baseline, and outpatient medication information were well balanced. Statin use was significantly associated with lower odds of the primary endpoint in the propensity-matched cohort (OR 0.48, 95% CI 0.36 aeuro" 0.64, p<0.001). We conclude that antecedent statin use in patients hospitalized with COVID-19 was associated with lower inpatient mortality. Randomized clinical trials evaluating the utility of statin therapy in patients with COVID-19 are needed. Twit Text FOAVip Association Between Antecedent Statin Use and Decreased Mortality in Hospitalized Patients with COVID-19 ????Res Sq http://www.kidney.de/pget.php?&tw=1&pmid=32818209 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=32818209 #FOAvip English Wikipedia <ref>{{Cite pmid|32818209}}</ref> Association Between Antecedent Statin Use and Decreased Mortality in Hospitalized Patients with COVID-19 #MMPMID32818209 Gupta A; Madhavan MV; Poterucha TJ; DeFilippis EM; Hennessey JA; Redfors B; Eckhardt C; Bikdeli B; Platt J; Nalbandian A; Elias P; Cummings MJ; Nouri SN; Lawlor M; Ranard LS; Li J; Boyle C; Givens R; Brodie D; Krumholz HM; Stone GW; Sethi SS; Burkhoff D; Uriel N; Schwartz A; Leon MB; Kirtane AJ; Wan EY; Parikh SA Res Sq 2020[Aug]; ä (ä): ä PMID32818209show ga The coronavirus disease 2019 (COVID-19), caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), can result in a hyperinflammatory state, leading to acute respiratory distress syndrome (ARDS), myocardial injury, and thrombotic complications, among other sequelae. Statins, which are known to have anti-inflammatory and antithrombotic properties, have been studied in the setting of other viral infections and ARDS, but their benefit has not been assessed in COVID-19. Thus, we sought to determine whether antecedent statin use is associated with lower in-hospital mortality in patients hospitalized for COVID-19. This is a retrospective analysis of patients admitted with COVID-19 from February 1 (st) through May 12 (th) , 2020 with study period ending on June 11 (th) , 2020. Antecedent statin use was assessed using medication information available in the electronic medical record. We constructed a multivariable logistic regression model to predict the propensity of receiving statins, adjusting for baseline socio-demographic and clinical characteristics, and outpatient medications. The primary endpoint included in-hospital mortality within 30 days. A total of 2626 patients were admitted during the study period, of whom 951 (36.2%) were antecedent statin users. Among 1296 patients (648 statin users, 648 non-statin users) identified with 1:1 propensity-score matching, demographic, baseline, and outpatient medication information were well balanced. Statin use was significantly associated with lower odds of the primary endpoint in the propensity-matched cohort (OR 0.48, 95% CI 0.36 aeuro" 0.64, p<0.001). We conclude that antecedent statin use in patients hospitalized with COVID-19 was associated with lower inpatient mortality. Randomized clinical trials evaluating the utility of statin therapy in patients with COVID-19 are needed. äAssociation Between Antecedent Statin Use and Decreased Mortality in H(epmc).pdf DeepDyve Pubget Overpricing