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10.1128/JCM.01695-20

http://scihub22266oqcxt.onion/10.1128/JCM.01695-20
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32817231!7587118!32817231
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suck abstract from ncbi

pmid32817231      J+Clin+Microbiol 2020 ; 58 (11): ä
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  • Challenges and Controversies to Testing for COVID-19 #MMPMID32817231
  • Binnicker MJ
  • J Clin Microbiol 2020[Oct]; 58 (11): ä PMID32817231show ga
  • The coronavirus disease (COVID-19) pandemic has placed the clinical laboratory and testing for SARS-CoV-2 front and center in the worldwide discussion of how to end the outbreak. Clinical laboratories have responded by developing, validating, and implementing a variety of molecular and serologic assays to test for SARS-CoV-2 infection. This has played an essential role in identifying cases, informing isolation decisions, and helping to curb the spread of disease. However, as the demand for COVID-19 testing has increased, laboratory professionals have faced a growing list of challenges, uncertainties, and, in some situations, controversy, as they have attempted to balance the need for increasing test capacity with maintaining a high-quality laboratory operation. The emergence of this new viral pathogen has raised unique diagnostic questions for which there have not always been straightforward answers. In this commentary, the author addresses several areas of current debate, including (i) the role of molecular assays in defining the duration of isolation/quarantine, (ii) whether the PCR cycle threshold value should be included on patient reports, (iii) if specimen pooling and testing by research staff represent acceptable solutions to expand screening, and (iv) whether testing a large percentage of the population is feasible and represents a viable strategy to end the pandemic.
  • |*Clinical Laboratory Techniques[MESH]
  • |Betacoronavirus/genetics/immunology/*isolation & purification[MESH]
  • |COVID-19[MESH]
  • |COVID-19 Testing[MESH]
  • |Clinical Laboratory Services/standards[MESH]
  • |Coronavirus Infections/*diagnosis/prevention & control[MESH]
  • |Humans[MESH]
  • |Mass Screening[MESH]
  • |Medical Laboratory Personnel/standards[MESH]
  • |Molecular Diagnostic Techniques/standards[MESH]
  • |Pandemics/prevention & control[MESH]
  • |Pneumonia, Viral/*diagnosis/prevention & control[MESH]
  • |Polymerase Chain Reaction/standards[MESH]
  • |Quarantine/standards[MESH]
  • |SARS-CoV-2[MESH]
  • |Sensitivity and Specificity[MESH]


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