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10.1007/s10654-020-00678-5 http://scihub22266oqcxt.onion/10.1007/s10654-020-00678-5 32816244!7438401!32816244     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Eur+J+Epidemiol 2020 ; 35 (8): 763-773 Nephropedia Template TP {{tp|p=32816244|t=2020. Anemia and iron metabolism in COVID-19: a systematic review and meta-analysis |pdf=|usr=}}{{32816244}} gab.com Text Anemia and iron metabolism in COVID-19: a systematic review and meta-analysis JO: Eur J Epidemiol http://www.kidney.de/pget.php?&tw=1&pmid=32816244 #FOAvip Iron metabolism and anemia may play an important role in multiple organ dysfunction syndrome in Coronavirus disease 2019 (COVID-19). We conducted a systematic review and meta-analysis to evaluate biomarkers of anemia and iron metabolism (hemoglobin, ferritin, transferrin, soluble transferrin receptor, hepcidin, haptoglobin, unsaturated iron-binding capacity, erythropoietin, free erythrocyte protoporphyrine, and erythrocyte indices) in patients diagnosed with COVID-19, and explored their prognostic value. Six bibliographic databases were searched up to August 3rd 2020. We included 189 unique studies, with data from 57,563 COVID-19 patients. Pooled mean hemoglobin and ferritin levels in COVID-19 patients across all ages were 129.7 g/L (95% Confidence Interval (CI), 128.51; 130.88) and 777.33 ng/mL (95% CI, 701.33; 852.77), respectively. Hemoglobin levels were lower with older age, higher percentage of subjects with diabetes, hypertension and overall comorbidities, and admitted to intensive care. Ferritin level increased with older age, increasing proportion of hypertensive study participants, and increasing proportion of mortality. Compared to moderate cases, severe COVID-19 cases had lower hemoglobin [weighted mean difference (WMD), - 4.08 g/L (95% CI - 5.12; - 3.05)] and red blood cell count [WMD, - 0.16 x 10(12) /L (95% CI - 0.31; - 0.014)], and higher ferritin [WMD, - 473.25 ng/mL (95% CI 382.52; 563.98)] and red cell distribution width [WMD, 1.82% (95% CI 0.10; 3.55)]. A significant difference in mean ferritin levels of 606.37 ng/mL (95% CI 461.86; 750.88) was found between survivors and non-survivors, but not in hemoglobin levels. Future studies should explore the impact of iron metabolism and anemia in the pathophysiology, prognosis, and treatment of COVID-19. Twit Text FOAVip Anemia and iron metabolism in COVID-19: a systematic review and meta-analysis ????Eur J Epidemiol http://www.kidney.de/pget.php?&tw=1&pmid=32816244 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=32816244 #FOAvip English Wikipedia <ref>{{Cite pmid|32816244}}</ref> Anemia and iron metabolism in COVID-19: a systematic review and meta-analysis #MMPMID32816244 Taneri PE; Gomez-Ochoa SA; Llanaj E; Raguindin PF; Rojas LZ; Roa-Diaz ZM; Salvador D Jr; Groothof D; Minder B; Kopp-Heim D; Hautz WE; Eisenga MF; Franco OH; Glisic M; Muka T Eur J Epidemiol 2020[Aug]; 35 (8): 763-773 PMID32816244show ga Iron metabolism and anemia may play an important role in multiple organ dysfunction syndrome in Coronavirus disease 2019 (COVID-19). We conducted a systematic review and meta-analysis to evaluate biomarkers of anemia and iron metabolism (hemoglobin, ferritin, transferrin, soluble transferrin receptor, hepcidin, haptoglobin, unsaturated iron-binding capacity, erythropoietin, free erythrocyte protoporphyrine, and erythrocyte indices) in patients diagnosed with COVID-19, and explored their prognostic value. Six bibliographic databases were searched up to August 3rd 2020. We included 189 unique studies, with data from 57,563 COVID-19 patients. Pooled mean hemoglobin and ferritin levels in COVID-19 patients across all ages were 129.7 g/L (95% Confidence Interval (CI), 128.51; 130.88) and 777.33 ng/mL (95% CI, 701.33; 852.77), respectively. Hemoglobin levels were lower with older age, higher percentage of subjects with diabetes, hypertension and overall comorbidities, and admitted to intensive care. Ferritin level increased with older age, increasing proportion of hypertensive study participants, and increasing proportion of mortality. Compared to moderate cases, severe COVID-19 cases had lower hemoglobin [weighted mean difference (WMD), - 4.08 g/L (95% CI - 5.12; - 3.05)] and red blood cell count [WMD, - 0.16 x 10(12) /L (95% CI - 0.31; - 0.014)], and higher ferritin [WMD, - 473.25 ng/mL (95% CI 382.52; 563.98)] and red cell distribution width [WMD, 1.82% (95% CI 0.10; 3.55)]. A significant difference in mean ferritin levels of 606.37 ng/mL (95% CI 461.86; 750.88) was found between survivors and non-survivors, but not in hemoglobin levels. Future studies should explore the impact of iron metabolism and anemia in the pathophysiology, prognosis, and treatment of COVID-19. |*Coronavirus Infections/diagnosis/epidemiology[MESH] |*Pandemics[MESH] |*Pneumonia, Viral/epidemiology[MESH] |Anemia/*diagnosis[MESH] |Betacoronavirus[MESH] |Biomarkers/analysis/blood[MESH] |COVID-19[MESH] |COVID-19 Testing[MESH] |Clinical Laboratory Techniques[MESH] |Coronavirus/*metabolism[MESH] |Erythropoietin[MESH] |Ferritins/blood[MESH] |Hemoglobins/analysis/metabolism[MESH] |Hepcidins/blood/metabolism[MESH] |Humans[MESH] |Iron/blood/*metabolism[MESH] |Receptors, Transferrin/blood[MESH] |SARS-CoV-2[MESH]Anemia and iron metabolism in COVID-19: a systematic review and meta-a(epmc).pdf DeepDyve Pubget Overpricing