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10.1089/ham.2020.0098

http://scihub22266oqcxt.onion/10.1089/ham.2020.0098
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32815745!?!32815745

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suck abstract from ncbi

pmid32815745      High+Alt+Med+Biol 2020 ; 21 (4): 409-416
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  • Mortality Attributed to COVID-19 in High-Altitude Populations #MMPMID32815745
  • Woolcott OO; Bergman RN
  • High Alt Med Biol 2020[Dec]; 21 (4): 409-416 PMID32815745show ga
  • Woolcott, Orison O., and Richard N. Bergman. Mortality attributed to COVID-19 in high-altitude populations. High Alt Med Biol. 21:409-416, 2020. Background: Since partial oxygen pressure decreases as altitude increases, environmental hypoxia could worsen Coronavirus Disease 2019 (COVID-19) patient's hypoxemia. We compared COVID-19 mortality at different altitudes. Methods: Retrospective analysis of population-level data on COVID-19 deaths was conducted in the United States (1,016 counties) and Mexico (567 municipalities). Mixed-model Poisson regression analysis of the association between altitude and COVID-19 mortality was conducted using individual-level data from 40,168 Mexican subjects with COVID-19, adjusting for multiple covariates. Results: Between January 20 and April 13, 2020, mortality rates were higher in U.S. counties located at >/=2,000 m elevation versus those located <1,500 m (12.3 vs. 3.2 per 100,000; p < 0.001). In Mexico, between March 13 and May 13, 2020, mortality rates were higher in municipalities located at >/=2,000 m versus those located <1,500 m (5.3 vs. 3.9 per 100,000; p < 0.001). Among Mexican subjects younger than 65 years, the risk of death was 36% higher in those living at >/=2,000 m versus those living at <1,500 m (adjusted incidence rate ratio [IRR]: 1.36; confidence interval [95% CI], 1.05-1.78; p = 0.022). Among Mexican men, the risk of death was 31% higher at >/=2,000 m versus that at <1,500 m (adjusted IRR: 1.31; 95% CI, 1.03-1.66; p = 0.025). No association between altitude and COVID-19 mortality was found among Mexican women or among Mexican subjects 65 years of age and older. Conclusions: Altitude is associated with COVID-19 mortality in men younger than 65 years.
  • |*Altitude[MESH]
  • |Adult[MESH]
  • |Age Factors[MESH]
  • |Aged[MESH]
  • |COVID-19/epidemiology/*mortality/therapy[MESH]
  • |Female[MESH]
  • |Humans[MESH]
  • |Intubation, Intratracheal/statistics & numerical data[MESH]
  • |Male[MESH]
  • |Mexico/epidemiology[MESH]
  • |Middle Aged[MESH]
  • |Prevalence[MESH]
  • |Retrospective Studies[MESH]
  • |SARS-CoV-2[MESH]
  • |Sex Factors[MESH]


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