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10.4269/ajtmh.20-0771

http://scihub22266oqcxt.onion/10.4269/ajtmh.20-0771
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32815514!7543844!32815514
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suck abstract from ncbi


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pmid32815514      Am+J+Trop+Med+Hyg 2020 ; 103 (4): 1608-1613
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  • Epidemiological Investigation of the First 135 COVID-19 Cases in Brunei: Implications for Surveillance, Control, and Travel Restrictions #MMPMID32815514
  • Wong J; Chaw L; Koh WC; Alikhan MF; Jamaludin SA; Poh WWP; Naing L
  • Am J Trop Med Hyg 2020[Oct]; 103 (4): 1608-1613 PMID32815514show ga
  • Studies on the early introduction of SARS-CoV-2 in a naive population have important epidemic control implications. We report findings from the epidemiological investigation of the initial 135 COVID-19 cases in Brunei and describe the impact of control measures and travel restrictions. Epidemiological and clinical information was obtained for all confirmed COVID-19 cases, whose symptom onset was from March 9 to April 5, 2020. The basic reproduction number (R0), incubation period, and serial interval (SI) were calculated. Time-varying R was estimated to assess the effectiveness of control measures. Of the 135 cases detected, 53 (39.3%) were imported. The median age was 36 (range = 0.5-72) years. Forty-one (30.4%) and 13 (9.6%) were presymptomatic and asymptomatic cases, respectively. The median incubation period was 5 days (interquartile range [IQR] = 5, range = 1-11), and the mean SI was 5.4 days (SD = 4.5; 95% CI: 4.3, 6.5). The reproduction number was between 3.9 and 6.0, and the doubling time was 1.3 days. The time-varying reproduction number (Rt) was below one (Rt = 0.91; 95% credible interval: 0.62, 1.32) by the 13th day of the epidemic. Epidemic control was achieved through a combination of public health measures, with emphasis on a test-isolate-trace approach supplemented by travel restrictions and moderate physical distancing measures but no actual lockdown. Regular and ongoing testing of high-risk groups to supplement the existing surveillance program and a phased easing of physical distancing measures has helped maintain suppression of the COVID-19 outbreak in Brunei, as evidenced by the identification of only six additional cases from April 5 to August 5, 2020.
  • |Adolescent[MESH]
  • |Adult[MESH]
  • |Aged[MESH]
  • |Betacoronavirus/*pathogenicity[MESH]
  • |Brunei/epidemiology[MESH]
  • |COVID-19[MESH]
  • |Child[MESH]
  • |Child, Preschool[MESH]
  • |Communicable Disease Control/methods/*organization & administration[MESH]
  • |Coronavirus Infections/diagnosis/*epidemiology/*prevention & control/transmission[MESH]
  • |Epidemiological Monitoring[MESH]
  • |Female[MESH]
  • |Humans[MESH]
  • |Incidence[MESH]
  • |Infant[MESH]
  • |Infectious Disease Incubation Period[MESH]
  • |Male[MESH]
  • |Middle Aged[MESH]
  • |Pandemics/*prevention & control[MESH]
  • |Patient Isolation/methods/*organization & administration[MESH]
  • |Pneumonia, Viral/diagnosis/*epidemiology/*prevention & control/transmission[MESH]
  • |Psychological Distance[MESH]
  • |Quarantine/methods/organization & administration[MESH]
  • |Risk Factors[MESH]
  • |SARS-CoV-2[MESH]


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