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10.1038/s41392-020-00269-6 http://scihub22266oqcxt.onion/10.1038/s41392-020-00269-6 32814760!7434851!32814760     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Signal+Transduct+Target+Ther 2020 ; 5 (1): 157 Nephropedia Template TP {{tp|p=32814760|t=2020. Comparison of nonhuman primates identified the suitable model for COVID-19 |pdf=|usr=}}{{32814760}} gab.com Text Comparison of nonhuman primates identified the suitable model for COVID-19 JO: Signal Transduct Target Ther http://www.kidney.de/pget.php?&tw=1&pmid=32814760 #FOAvip Identification of a suitable nonhuman primate (NHP) model of COVID-19 remains challenging. Here, we characterized severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection in three NHP species: Old World monkeys Macaca mulatta (M. mulatta) and Macaca fascicularis (M. fascicularis) and New World monkey Callithrix jacchus (C. jacchus). Infected M. mulatta and M. fascicularis showed abnormal chest radiographs, an increased body temperature and a decreased body weight. Viral genomes were detected in swab and blood samples from all animals. Viral load was detected in the pulmonary tissues of M. mulatta and M. fascicularis but not C. jacchus. Furthermore, among the three animal species, M. mulatta showed the strongest response to SARS-CoV-2, including increased inflammatory cytokine expression and pathological changes in the pulmonary tissues. Collectively, these data revealed the different susceptibilities of Old World and New World monkeys to SARS-CoV-2 and identified M. mulatta as the most suitable for modeling COVID-19. Twit Text FOAVip Comparison of nonhuman primates identified the suitable model for COVID-19 ????Signal Transduct Target Ther http://www.kidney.de/pget.php?&tw=1&pmid=32814760 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=32814760 #FOAvip English Wikipedia <ref>{{Cite pmid|32814760}}</ref> Comparison of nonhuman primates identified the suitable model for COVID-19 #MMPMID32814760 Lu S; Zhao Y; Yu W; Yang Y; Gao J; Wang J; Kuang D; Yang M; Yang J; Ma C; Xu J; Qian X; Li H; Zhao S; Li J; Wang H; Long H; Zhou J; Luo F; Ding K; Wu D; Zhang Y; Dong Y; Liu Y; Zheng Y; Lin X; Jiao L; Zheng H; Dai Q; Sun Q; Hu Y; Ke C; Liu H; Peng X Signal Transduct Target Ther 2020[Oct]; 5 (1): 157 PMID32814760show ga Identification of a suitable nonhuman primate (NHP) model of COVID-19 remains challenging. Here, we characterized severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection in three NHP species: Old World monkeys Macaca mulatta (M. mulatta) and Macaca fascicularis (M. fascicularis) and New World monkey Callithrix jacchus (C. jacchus). Infected M. mulatta and M. fascicularis showed abnormal chest radiographs, an increased body temperature and a decreased body weight. Viral genomes were detected in swab and blood samples from all animals. Viral load was detected in the pulmonary tissues of M. mulatta and M. fascicularis but not C. jacchus. Furthermore, among the three animal species, M. mulatta showed the strongest response to SARS-CoV-2, including increased inflammatory cytokine expression and pathological changes in the pulmonary tissues. Collectively, these data revealed the different susceptibilities of Old World and New World monkeys to SARS-CoV-2 and identified M. mulatta as the most suitable for modeling COVID-19. |*Disease Models, Animal[MESH] |*Pandemics[MESH] |Animals[MESH] |Antibodies, Viral/biosynthesis[MESH] |Betacoronavirus/immunology/*pathogenicity[MESH] |Body Temperature[MESH] |Body Weight[MESH] |COVID-19[MESH] |Callithrix/immunology/*virology[MESH] |Coronavirus Infections/diagnostic imaging/*epidemiology/immunology/pathology[MESH] |Cytokines/biosynthesis/classification/immunology[MESH] |Disease Susceptibility[MESH] |Female[MESH] |Humans[MESH] |Lung/diagnostic imaging/immunology/pathology/virology[MESH] |Macaca fascicularis/immunology/*virology[MESH] |Macaca mulatta/immunology/*virology[MESH] |Male[MESH] |Pneumonia, Viral/diagnostic imaging/*epidemiology/immunology/pathology[MESH] |SARS-CoV-2[MESH] |Species Specificity[MESH] |Tomography, X-Ray Computed[MESH] |Viral Load[MESH]Comparison of nonhuman primates identified the suitable model for COVI(epmc).pdf DeepDyve Pubget Overpricing